grant
A prospective study of viral infections and subsequent risk of Alzheimer’s disease
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 1 Feb 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY202621+ years old3'-5'-CpGAD biological markerAD biomarkerAD dementiaAD preventionAD related biomarkerAD riskAD risk factorAIDS VirusAbeta synthesisAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActive Follow-upAddressAdultAdult HumanAgeAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer disease preventionAlzheimer preventionAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's biomarkerAlzheimer's disease biological markerAlzheimer's disease biomarkerAlzheimer's disease related biomarkerAlzheimer's disease riskAlzheimer's related biomarkerAlzheimers DementiaAlzheimer’s biological markerAmentiaAmericanAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β productionAmyloid β synthesisAmyloid β-PeptideAmyloid β-ProteinAntibody ResponseAppearanceAreaAstroproteinAβAβ productionAβ synthesisBacteriophagesBlood SampleBlood SerumBlood specimenBrainBrain Nervous SystemCG-dinucleotideCMVCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCausalityCenters for Medicare and Medicaid ServicesChronologyClinicalCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollectionComplexCpG dinucleotideCytomegalovirusDNA MethylationDementiaDetectionDevelopmentDiagnosticDiseaseDisorderDisturbance in cognitionEarly InterventionElderlyEncephalonEnrollmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyExposure AssessmentFaceFemale HealthFutureGFA-ProteinGFAPGenomeGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinHBVHCMVHHV 5HHV5HIVHealthHealth Care Financing AdministrationHepatitis B VirusHerpesviridaeHerpesvirus 5 (beta), HumanHerpesvirusesHigh Throughput AssayHistoryHumanHuman FigureHuman Herpesvirus 5Human Immunodeficiency VirusesHuman bodyImmune PrecipitationImmune responseImmunityImmunoprecipitationImpaired cognitionIndividualInfectionInflammatoryJointsLAV-HTLV-IIILightLinkLong-term cohortLongitudinal cohortLymphadenopathy-Associated VirusMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodologyMethodsModern ManNMR ImagingNMR TomographyNested Case-Control StudyNeuropsychologic TestsNeuropsychological TestsNeuropsychologiesNeuropsychologyNuclear Magnetic Resonance ImagingOutcomeParticipantPatient RecruitmentsPhIP-seqPhage ImmunoPrecipitation SequencingPhagesPhasePhenotypePhotoradiationPrevalencePreventative measurePreventionPreventive measurePrimary PreventionPrimary Senile Degenerative DementiaProcessProspective StudiesProspective cohortProspective, cohort studyPublic HealthRecording of previous eventsResearchResearch DesignRiskRisk AssessmentRisk FactorsRoleSalivary Gland VirusesSamplingSerologySerumSiteStatistical MethodsStudy TypeSymptomsTimeUnited StatesUnited States Centers for Medicare and Medicaid ServicesUnited States Health Care Financing AdministrationUpregulationValidationViralViral AntibodiesViral DiseasesVirusVirus DiseasesVirus-HIVWomanWomen's HealthWorkZeugmatographya beta peptideabetaabeta productionaccelerated agingaccelerated biological ageaccelerated biological agingaccelerated epigenetic ageaccelerated epigenetic agingaccelerated pace of epigenetic agingacceleration in epigenetic ageactive followupadulthoodadvanced ageage accelerationaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsagesaging populationalzheimer riskamyloid betaamyloid beta productionamyloid beta synthesisamyloid-b proteinanti-viral antibodybacterial virusbeta amyloid fibrilbiomarker in ADbiomarker in Alzheimer'sbiomarker in Alzheimer's diseasebrain healthcase controlcase-control surveycase-controlledcase-controlled studiescausationcognitive changecognitive dysfunctioncognitive functioncognitive losscognitive reservecohortcytidine monophosphate guanosinecytidylyl-3'-5'-guanosinecytokinecytomegalovirus groupcytosine-guanine dinucleotidedementia burdendementia riskdevelopmentaldisease causationenrollepidemiology research studyepidemiology studyepidemiology surveyepigeneticallyexposure analysisexposure evaluationexposure measurementexposure profilingexposure surveyfacesfacialfaster epigenetic agingfaster rates of epigenetic agingfollow upfollow-upfollowed upfollowupgeriatricherpes virushigh throughput screeninghistorieshost responsehuman betaherpesvirus 5human viromehyper-phosphorylated tauhyperphosphorylated tauimmune system responseimmunoresponseimprovedincreased epigenetic ageincreased epigenetic agingincreased rates of epigenetic aginginsightlate in lifelate lifelater in lifelater lifelife spanlifespanmethylation patternmid lifemid-lifemiddle agemiddle agedmidlifenerve cell deathnerve cell lossneural imagingneural networkneuro-imagingneurofilamentneuroimagingneurological imagingneuron cell deathneuron cell lossneuron deathneuron lossneuronal cell deathneuronal cell lossneuronal deathneuronal lossneuropathologicneuropathologicalneuropathologyneuropsychologicnew technologynovelnovel technologiesp-taup-τparticipant recruitmentpathogenpathogenic virusphospho-tauphospho-τphosphorylated taupopulation agingpost-translational modification of tauposttranslational modification of tauprimary degenerative dementiaprospectiveprospective research studyprospective surveyrapid epigenetic agingresponserisk factor for dementiarisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk for dementiarisk of developing Alzheimer'srisk stratificationsenile dementia of the Alzheimer typesenior citizensocial rolesoluble amyloid precursor proteinstatistic methodsstratify riskstudy designtau phosphorylationtau posttranslational modificationtau-1validationsviral infectionviral pathogenvirus infectionvirus pathogenvirus-induced diseaseτ phosphorylation
Description preview
SUMMARY
The prevalence of Alzheimer’s disease (AD), the most common form of dementia, is expected to triple and reach
13 million in the United States by the year 2050. Despite the public health burden of dementia on an aging
population, the etiology of AD is still not well-understood. The interplay between the human virome—the total
collection of…
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