grant
A prospective study of circulating autoantibodies and breast cancer risk in the NYU Women’s Health Study
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AccountingActive Follow-upAcuteAddressAntibodiesAntigen-Antibody ComplexAntigensApoptoticAssayAutoantibodiesAutoantigensAutologous AntigensAutoregulationBioassayBiological AssayBiological MarkersBirthBloodBlood Reticuloendothelial SystemBlood SampleBlood SerumBlood specimenBreast CancerBreast Cancer PreventionBreast Cancer Risk FactorCalibrationCancer ControlCancer Control ScienceCancerousCancersCell BodyCellsCharacteristicsCollaborationsComplement ActivationCross ReactionsDNA mutationDataData CollectionDevelopmentDiagnosisDiagnosticELISAEarly DiagnosisElectronic Health RecordEnrollmentEnsureEnzyme-Linked Immunosorbent AssayEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEquilibriumEthnic OriginEthnicityEvolutionFemale HealthFloridaFutureGenetic ChangeGenetic defectGenetic mutationGoalsHomeostasisHormonalHumanImmuneImmune ComplexImmune EvasionImmune SurveillanceImmune mediated therapyImmune reactionImmune responseImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologic SurveillanceImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunosurveillanceImmunotherapyIndividualInflammationInvestigationK CellsKiller CellsMacrophageMalignant Breast NeoplasmMalignant NeoplasmsMalignant TumorMeasurableMeasuresMediatingMedical RecordsModern ManMutationMφNested Case-Control StudyNew YorkParticipantParturitionPhasePhysiological HomeostasisPlayPrecancerous CellsPremalignant CellProcessProspective StudiesProspective, cohort studyProteomeReactionResearchRiskRisk AssessmentRisk FactorsRoleSamplingSelf-AntigensSerumSiteSystemTestingTimeTumor EscapeTumor Immune EscapeTumor SubtypeUniversitiesValidationWomanWomen's Healthactive followupagedautoimmune antibodyautoreactive antibodybalancebalance functionbio-markersbiobankbiologic markerbiomarkerbiomarker identificationbiorepositorybreast cancer riskcancer diagnosiscancer evasioncancer immune escapecancer immune evasioncancer registrycase controlcase-controlledcell transformationcohortcomplement pathway regulationcytotoxic CD8 T cellscytotoxic CD8 T lymphocytedata harmonizationdata integrationdevelopmentaldietarydifferences due to racedifferences in racediffers by racediffers in raceearly detectionelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordenrollenzyme linked immunoassayepidemiologic investigationepidemiology studyexperimentexperimental researchexperimental studyexperimentsfollow upfollow-upfollowed upfollowupgenome mutationharmonized datahost responseidentification of biomarkersidentification of new biomarkersimmune evasiveimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunoreactionimmunoresponseimprovedinnovateinnovationinnovativeinsightinterestmalignancymalignant breast tumormammary cancer preventionmammary tumor preventionmarker identificationneoplasm registryneoplasm/cancernew technologynovel technologiesoverexpressoverexpressionprecancerprecancerouspremalignantpreventprevent breast cancerpreventingprospectiverace based differencesrace differencesrace related differencesracial differenceracially differentrecruitrisk stratificationself reactive antibodysocial rolestratify risksuccesstransformed cellstumortumor evasiontumor immune evasiontumor registryvalidationsvirtual
Description preview
SUMMARY
Breast cancer is the most commonly diagnosed cancer among US women, accounting for ~30% of all new
cancer cases in women. Identifying biomarkers associated with breast cancer risk may reveal new
pathophysiological mechanisms and potentially lead to improvements in risk stratification. The immune system
is known to play a critical role in…
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