grant
A Platform for Scalable Spatial Somatic Variant Profiling
Organization BROAD INSTITUTE, INC.Location CAMBRIDGE, UNITED STATESPosted 19 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAgingAssayAssay for Transposase-Accessible Chromatin using sequencingBar CodesBenchmarkingBest Practice AnalysisBioassayBiological AssayBody TissuesCell BodyCellsClonal ExpansionComputational toolkitComputer Software ToolsComputer softwareCuesDNADNA mutationDNA seqDNA sequencingDNAseqDataData SetDeoxyribonucleic AcidDiseaseDisorderDysfunctionEnsureEpitheliumEquipmentFunctional disorderGene ExpressionGene FrequencyGene variantGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomicsGoalsGroupingIndividualMeasurementMeasuresMethodsModalityMorphologyMosaicismMutationNeighborhoodsPhysiopathologyProcessProtocolProtocols documentationPublicationsRNA SeqRNA sequencingRNAseqResearchResolutionSamplingScientific PublicationSlideSoftwareSoftware ToolsSomatic MutationTechnologyTechnology TransferTimeTissuesVariantVariationWorkadverse consequenceadverse outcomeallelic frequencyallelic variantassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbarcodebenchmarkcell typecomputational toolboxcomputational toolscomputational toolsetcomputerized toolsdata qualitydevelop softwaredeveloping computer softwareepigenomeepigenomicsfitnessfunctional outcomesgene panelgenetic variantgenome mutationgenomic variantglobal gene expressionglobal transcription profilegroupingshuman tissueimprovedinsightinterestmembermigrationmosaic diseasesmosaic disordersmultigene panelmultiomicsmultiple omicsnovelpanomicspathophysiologyprogenitor cell differentiationprogenitor cell expansionprogenitor differentiationprogenitor expansionresolutionssoftware developmentsoftware toolkitsomatic variantspatial multiomicsspatial omicsspatial tri-omicsstem and progenitor cell expansionstem and progenitor differentiationstem cell differentiationstem cell expansiontechnology platformtechnology systemtooltranscriptometranscriptome sequencingtranscriptomic sequencingvariant detection
Description preview
SUMMARY
Recent studies have begun to characterize the accumulation of somatic mutations over the
lifetime of an individual. A variety of mutational processes, both cell-intrinsic and -extrinsic,
underpin these mutations, which if occurring in key driver genes, may alter the fitness of the cell
and lead to adverse outcomes. However, much work is…
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