grant
A platform for scalable spatial single cell genomics
Organization BROAD INSTITUTE, INC.Location CAMBRIDGE, UNITED STATESPosted 8 Aug 2019Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025ArchitectureAreaBody TissuesBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsChromatinClinicalCommunicationComplexDNA MethylationDNA SequenceDevelopmentDiseaseDisorderDissociationDysfunctionEncephalonEngineering / ArchitectureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFunctional disorderGene ExpressionGene TranscriptionGenetic TranscriptionGenomeGenomicsHistopathologyHumanHuman FigureHuman bodyIn SituIndividualIntracellular Communication and SignalingLengthLewy BodiesLightMapsMeasurementMeasuresMethodologyMicroscopyModalityModelingModern ManMolecularMorphologyNormal TissueNormal tissue morphologyNucleusOrganParaffin EmbeddingPathologyPatternPhotoradiationPhysiopathologyPositionPositioning AttributeProcessProteinsProtocolProtocols documentationRNA ExpressionRecoveryRegulationResearch SpecimenResolutionRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSlideSomatic MutationSpecimenStructureSubstantia NigraSubstantia nigra structureSurfaceSurvey InstrumentSurveysSuspension substanceSuspensionsTechnologyTissue EmbeddingTissue imagingTissuesTranscriptionVariantVariationWorkbiological signal transductioncell typedevelopmentalepigeneticallyepigenomeepigenomicsfrontal cortexfrontal lobegenomic toolsglobal gene expressionglobal transcription profilehuman diseasehuman tissueimage-based methodimaging methodimaging modalityimprovedinnovateinnovationinnovativeinventionmulti-modalitymultimodalitymultiomicsmultiple omicsnew technologynovel technologiespanomicspathophysiologypreservationreconstructionresolutionssingle cell genomicssingle cell technologysocial rolesomatic variantspatial multiomicsspatial omicsspatial tri-omicstechnology platformtechnology systemtooltranscriptome
Description preview
SUMMARY
The function of human tissues is dependent upon complex interactions amongst millions of substituent cells.
Tools that can systematically measure transcriptional and epigenetic states of these cells, while also recording
their spatial positions, hold great promise in understanding both normal tissue function and its dysfunction in
disease…
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