grant
A Pathogenic Role for the Natriuretic Peptide Clearance Receptor in Heart Failure with Preserved Ejection Fraction.
Organization VETERANS HEALTH ADMINISTRATIONLocation NASHVILLE, UNITED STATESPosted 1 Jul 2023Deadline 30 Mar 2028
VANIHUS FederalResearch GrantFY20253'5'-cyclic ester of AMPAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine Cyclic Monophosphate-Dependent Protein KinasesAdenosine, cyclic 3',5'-(hydrogen phosphate)Adipose tissueAdvisory CommitteesAffectAnimal ModelAnimal Models and Related StudiesBiogenesisBiopsy SampleBiopsy SpecimenBody TissuesCRISPRCRISPR/Cas systemCardiacCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiac OutputCardiocyteCause of DeathCell BodyCell Communication and SignalingCell SignalingCellsCessation of lifeClustered Regularly Interspaced Short Palindromic RepeatsCommunicationCyclic AMPCyclic AMP-Dependent Protein KinasesCyclic GMPDataDeathDevelopmentDiastolic heart failureDiseaseDisorderFailureFatty TissueFoundationsFundingGenerationsGenesGenus HippocampusGoalsGuanosine Cyclic MonophosphateHF with preserved ejection fractionHFpEFHeartHeart DiseasesHeart Muscle CellsHeart failureHeart myocyteHospital AdmissionHospitalizationHumanHypertrophyImpairmentIn VitroIntermediary MetabolismIntracellular Communication and SignalingKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLigandsMeasurementMeasuresMediatingMentorsMentorshipMetabolicMetabolic ProcessesMetabolic dysfunctionMetabolismMethodsMitochondriaModelingModern ManMorbidityMorbidity - disease rateMyocardialNatriuresisNatriuretic Peptide HormonesNatriuretic PeptidesNull MouseObesityOrigin of LifeOutcomePGC1a Regulation PathwayPKAPathogenesisPathogenicityPathway interactionsPhysiciansPrincipal InvestigatorProtein Kinase ART-PCRReceptor ProteinRegulationRegulation of PGC-1aRelaxationResearchResearch ResourcesResourcesRespirationReverse Transcriptase Polymerase Chain ReactionRight Ventricular DysfunctionRight Ventricular FunctionRight heart dysfunctionRight ventricle dysfunctionRight-sided heart dysfunctionRoleScientistSeahorseSignal TransductionSignal Transduction SystemsSignalingStructureSurfaceTask ForcesTechniquesTestingTissuesTrainingTraining SupportTransgenic MiceTransgenic OrganismsVentricularVeteransWorkadenosine 3'5' monophosphateadiposeadiposityadvisory teambiological signal transductioncAMPcAMP-Dependent Protein KinasescGMPcardiac failurecardiac metabolismcardiomyocytecareercareer developmentcorpulencedevelopmentalexercise capacityfatty acid oxidationheart disorderheart failure with preserved ejection fractionheart failure with preserved systolic functionheart metabolismheart outputhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPSiPSCiPSCsimprovedimproved outcomein vivoinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellknock-downknockdownmetabolism measurementmetabolomicsmetabonomicsmitochondrialmitochondrial dysfunctionmodel of animalmortalitymyocardial biopsynew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetobesity interventionobesity therapyobesity treatmentoverexpressoverexpressionpathwaypatient populationpharmacologicpreserved ejection fraction heart failurepreventpreventingprotein expressionreceptorrespiratory mechanismreverse transcriptase PCRright heart failureright sided heart failureright ventricle failureright ventricular failureright ventricular heart failureskillssocial roletherapeutic evaluationtherapeutic targettherapeutic testingtransgenicwhite adipose tissueyellow adipose tissue
Description preview
PROJECT SUMMARY
Heart failure with preserved ejection fraction (HFpEF) affects almost 2.5% of all US Veterans, and it
contributes to nearly 1 in 14 deaths in Veterans. Unlike other forms of heart failure, there are currently no
treatment options for HFpEF that reduce mortality. A common cause of morbidity and mortality in HFpEF is
right…
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