grant
A Novel Wavelet Neurovascular Bundle for Real Time Detection of Injury in Neonatal Encephalopathy
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 15 Jul 2017Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20250-4 weeks oldAcquired brain injuryActive Follow-upAcuteAffectAlternative TherapiesAlternative interventionAsphyxiaAutoregulationBiochemicalBiologicalBiological MarkersBiomedical EngineeringBirthBlood VesselsBrainBrain InjuriesBrain Nervous SystemCell Communication and SignalingCell SignalingCessation of lifeCirculationClassificationClinicalCognitiveCouplingDataDeathDetectionDevelopmentEEGElectroencephalogramElectroencephalographyElectrophysiologyElectrophysiology (science)EncephalonEncephalopathiesEnrollmentEnsureEnvironmentEvolutionFailureFamilyFundingFutureGoalsHomeostasisHospitalsHourHypothermiaImageImpairmentIndividualInfantInfrastructureInjuryIntermediary MetabolismInterventionIntracellular Communication and SignalingInvestigatorsKnowledgeLifeMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMapsMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMetabolic ProcessesMetabolismMissionMonitorNINDSNMR ImagingNMR TomographyNational Institute of Neurological Diseases and StrokeNational Institute of Neurological Disorders and StrokeNational Institutes of HealthNeonatal MortalityNeonatal asphyxia-induced brain injuryNeonatal hypoxic brain injuryNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurodevelopmental ImpairmentNeurologicNeurologic DisordersNeurologicalNeurological DisordersNeuronsNeurophysiology / ElectrophysiologyNewborn InfantNewbornsNuclear Magnetic Resonance ImagingO elementO2 elementOutcomeOxygenOxygen ConsumptionParturitionPatient SelectionPerfusionPhasePhysiologicPhysiologicalPhysiological HomeostasisPopulationPredictive ValueProcessPublic HealthPublicationsRandomization trialRelaxationResearchResearch PersonnelResearchersScientific PublicationSeveritiesSignal TransductionSignal Transduction SystemsSignalingSocioeconomic FactorsSpectroscopySpectrum AnalysesSpectrum AnalysisStratificationStructureSuffocationSupportive TherapySupportive careSurrogate End PointsSurrogate EndpointSystemSystematicsTestingTherapeuticTherapeutic InterventionTimeTreatment EfficacyUnited States National Institutes of HealthVulnerable PopulationsWorkZeugmatographyactive followupasphyxiationbio-engineeredbio-engineersbio-markersbioengineeringbiologicbiologic markerbiological engineeringbiological signal transductionbiomarkerbrain damagebrain healthbrain-injuredclinical examclinical examinationcohortcommunity engagementcomputer based predictiondeath among neonatesdeath among newbornsdeath in neonatesdeath in newborndevelopmentaldisabilitydisability riskelectrophysiologicalengagement with communitiesenrollfollow upfollow-upfollowed upfollowupfunctional outcomeshemodynamicshypoxic ischemic encephalopathyimagingimprovedimproved outcomeinjuriesinsightintervention efficacyintervention therapymetabolic ratemodel designmortality among neonatesmortality among newbornsmortality in neonatesmortality in newbornsmulti-modalitymultidisciplinarymultimodalitynatural hypothermianeonatal HIEneonatal brain hypoxia-ischemianeonatal deathneonatal demiseneonatal encephalopathyneonatal hypoxia-ischemianeonatal hypoxic-ischemic brain damageneonatal hypoxic-ischemic brain injuryneonatal hypoxic-ischemic encephalopathyneonateneural imagingneuro-imagingneuro-vascularneuro-vascular couplingneurobiological mechanismneuroimagingneuroimaging biomarkerneuroimaging markerneurological diseaseneurological imagingneuronalneurophysiologicalneurophysiologyneuroprotectionneuroprotectiveneurovascularneurovascular couplingnewborn childnewborn childrennewborn deathnewborn mortalitynoveloutcome predictionparent grantpostnatalpredictive biological markerpredictive biomarkerspredictive markerpredictive modelingpredictive molecular biomarkerprimary outcomerandomized trialsecondary outcomesocio-economic factorssuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic efficacytherapy efficacyvascularvulnerable groupvulnerable individualvulnerable people
Description preview
Hypoxic-ischemic encephalopathy (HIE) is the leading cause of newborn death and disability
worldwide and presents clinically as neonatal encephalopathy that is difficult to classify within a
short window after birth to inform neuroprotective interventions. Therapeutic hypothermia (TH)
has dramatically improved outcomes in moderate to severe HIE…
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