grant
A novel target in aged fracture healing
NIHUS FederalResearch GrantFY20257S Gamma GlobulinAPOEAffectAgeAgingAntibodiesApo-EApoE proteinApolipoprotein EBM Stem CellBM derived progenitorBM progenitorBM- derived Stem CellsBiologyBody TissuesBone Marrow Stem CellBone Marrow progenitorBone RegenerationBone TissueBone callusBony CallusCallusCell Communication and SignalingCell Culture TechniquesCell SignalingCell Surface ReceptorsCell surfaceCirculationClinicDataDepositDepositionDoseElderlyFractureFracture HealingHealthHepatic CancerHepatic CellsHepatic Parenchymal CellHepatocyteHumanIgGImmunoglobulin GImpairmentIn VitroInjuryInterventionIntracellular Communication and SignalingLigandsLiteratureLiverLiver CellsLoxP-flanked alleleMUSK geneMalignant neoplasm of liverMechanicsMiceMice MammalsModelingModern ManMorbidityMorbidity - disease rateMouse Homolog of Receptor Tyrosine Kinase NSK2MurineMusMuscle, Skeletal, Receptor Tyrosine KinaseMuscle-Specific KinaseMyoneural JunctionNSK2Neuromuscular JunctionOperative ProceduresOperative Surgical ProceduresOrthopedicOrthopedic Surgical ProfessionOrthopedicsOsteoblastsOutcomePTK ReceptorsPathway interactionsPatientsPhenotypePhosphorylationPopulationProtein PhosphorylationProteinsPublic HealthPublishingReceptor ProteinReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneReceptor Tyrosine Kinase MuSKRegimenReportingRoleShort interfering RNASignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmall Interfering RNASurgicalSurgical InterventionsSurgical ProcedureTestingTherapeuticTimeTissuesTranscriptTransgenic MiceTranslatingTransmembrane Receptor Protein Tyrosine KinaseTreatment ProtocolsTreatment RegimenTreatment ScheduleTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsWorkadvanced ageage associatedage correlatedage dependentage linkedage relatedage specificagedaged boneaged miceaged mouseagesbiological signal transductionbonebone agingbone fracturebone fracture healingbone fracture repairbone healingbone marrow derived progenitorbone marrow derived stem cellsbone marrow stromal cellbone marrow stromal stem cellbone repairbone wound healingcell culturecell culturesclinical translationclinically translatablecohortcostdeliver short interfering RNAdeliver siRNAdeliver small interfering RNAdelivery system for siRNAdelivery system for small interfering RNAdelivery vectors for siRNAdevelop therapyelderly micefloxedfloxed allelefracture repairgeriatrichealth care burdenhepatic body systemhepatic organ systemimprovedinduced Creinducible Creinhibitorinjuriesintervention developmentknock-downknockdownliver cancerliver malignancymalemalignant liver tumormechanicmechanicalmineralizationmortalitymouse Cre recombinasemouse modelmurine modelneutralizing antibodynovelold miceolder adultolder adulthoodoptimal therapiesoptimal treatmentsosseous wound healingosteoblast cell differentiationosteoblast differentiationosteoblast progenitorosteoblast stem cellosteoblastic differentiationosteogenicosteogenic progenitorosteogenic stem cellosteoprogenitorosteoprogenitor cellpathwaypre-clinicalpreclinicalpreventpreventingprotein expressionreceptorregenerate bonescRNA sequencingscRNA-seqsenior citizenshort interfering RNA deliverysiRNAsiRNA deliverysingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall interfering RNA deliverysocial rolesurgerytherapeutic targettherapy developmenttissue culturetreatment development♂
Description preview
ABSTRACT
Bone fractures occur in 50% of the population causing significant morbidity and mortality and costing more than
$20 billion annually. Advanced age diminishes bone repair capacity and is associated with increased surgical
intervention at the time of the injury and subsequently with the need for revisions. The development of therapies
aimed…
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