grant
A novel platform for nonribosomal peptide discovery
Organization CHEMIA BIOSCIENCES, INC.Location PITTSBURGH, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20253-D structure3-dimensional structure3D structureAcademiaActinomycesAgricultureAmino AcidsAnti-Bacterial AgentsAntibiotic AgentsAntibiotic DrugsAntibioticsBenchmarkingBest Practice AnalysisCandida resistanceCandida resistant isolateCapitalCatalogsChemical StructureChemicalsChemistryCloud ServiceCollaborationsCollectionComplexComputational TechniqueComputer softwareComputersComputing MethodologiesCyclicityDataData BasesData SetDatabasesDrug ImpurityDrug KineticsDrug resistanceDrugsESKAPEESKAPE pathogensEnzyme GeneEnzymesFood and Drug AdministrationFungal Multidrug ResistanceFungal Multidrug ResistantFutureGeneHomologGenomeGoalsHomologHomologous GeneHomologueHydrogen OxideIndustryLabelLeadLettersLibrariesMacromolecular StructureMarkov ChainsMarkov ProcessMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicationMethodsMiceMice MammalsMichiganMiningMiscellaneous AntibioticModificationMolecularMolecular StructureMultiple Anti-fungal Drug ResistanceMultiple Anti-fungal Drug ResistantMultiple Antifungal Drug ResistanceMultiple Antifungal Drug ResistantMultiple Fungal Drug ResistanceMurineMusNatural ProductsPatternPb elementPeptidesPeriodicityPharmaceutical PreparationsPharmacokineticsPhasePlantsPrivatizationPubChemReadabilityReportingResistance to Multiple Anti-fungal DrugResistance to Multiple Antifungal DrugResistant candidaResistant to Multiple Anti-fungal DrugResistant to Multiple Antifungal DrugRhythmicityRunningSafetyScientistServicesSiteSoftwareSourceSpecificityStreptomycesStructureTechniquesTestingTherapeutic FungicidesUSFDAUnited States Food and Drug AdministrationValidationVariantVariationWateradenylateaminoacidanti-bacterialanti-fungalanti-fungal agentsanti-fungal druganti-microbialantimicrobialautoencoderautoencoding neural networkbenchmarkcatalogcloud basedcomplex datacomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methoddata basedata base structuredata to traindatabase structuredataset to traindevelop softwaredeveloping computer softwaredrug resistantdrug/agentfungal pathogenfungi pathogengenomic datagenomic datasetheavy metal Pbheavy metal leadhigh throughput technologyimprovedin vivointerestlearning activitylearning methodlearning strategieslearning strategymetabolism measurementmetabolomicsmetabonomicsmicrobes genomemicrobialmicrobial genomemicrobial productsnaturally occurring productnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenpathogenic fungusresistance among Candidaresistance in Candidaresistance to Drugresistant Candida strainsresistant to Drugscaffoldscaffoldingscreeningscreeningssearch enginesmall moleculesoftware developmenttandem mass spectrometrythree dimensional structuretraining datatumorvalidations
Description preview
Project Summary.
Natural products are the major source of drug molecules. Currently, 64% of small molecule drugs approved by
the Food and Drug Administration are natural products or their derivatives. Currently, the dominant technique for
discovering novel natural products is bioactivity-guided isolation. However, this technique is limited to the…
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