grant
A novel live biologic for the prevention and treatment of NEC-induced neurodevelopmental impairment
Organization RESEARCH INST NATIONWIDE CHILDREN'S HOSPLocation COLUMBUS, UNITED STATESPosted 19 Sept 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY20251,2,3-Propanetriol1,2,3-TrihydroxypropaneAcquired brain injuryAdherenceAffectAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntiinflammatory EffectAttenuatedAutomobile DrivingBacteriaBacterial TranslocationBiologic SciencesBiologicalBiological SciencesBioscienceBirthBrainBrain InjuriesBrain Nervous SystemCessation of lifeClinical ResearchClinical StudyClinical TrialsCommon Rat StrainsComplexCoupledDataDeathDevelopmentDiseaseDisorderDoseEarly-Stage Clinical TrialsEncephalonExposure toFDA approvedFormulationFutureGestationGlycerinGlycerolGoalsH2 ReceptorsH2 geneH2RHRH2HRH2 geneHistamineHistamine H2 ReceptorsHistidineHypothermiaHypoxiaHypoxicIncidenceIndolesInfectionInflammationInflammatory ResponseIntestinalIntestinesL-TryptophanLeadLevotryptophanLifeLife SciencesLinkMOF syndromeMicrobeadsMicrobial BiofilmsMicrospheresModelingMultiple Organ Dysfunction SyndromeMultiple Organ FailureNecrosisNecroticNecrotizing EnterocolitisNeonatalNeural DevelopmentNeurodevelopmental ImpairmentOxygen DeficiencyParturitionPathway interactionsPb elementPhase 1 Clinical TrialsPhase I Clinical TrialsPorosityPredispositionPregnancyPremature InfantPreventionProbioticsProductionPropertyRatRats MammalsRattusRegimenResearchRiskRoleSepsisSurfaceSurvivorsSusceptibilitySystemTestingTherapeuticTimeTranslational ResearchTranslational ScienceTryptophanTryptophan MetabolismTryptophan Metabolism Pathwayadverse event riskanti-inflammatory effectanti-microbialantimicrobialattenuateattenuatesattenuationbehavior outcomebehavioral outcomebiocompatibilitybiofilmbiologicbiomaterial compatibilitybowelbowel inflammationbrain damagebrain-injureddevelopmentaldrivingdysbacteriosisdysbiosisdysbioticearly life stressexperimentexperimental researchexperimental studyexperimentsfeedinggut inflammationgut microbesgut microbial speciesheavy metal Pbheavy metal leadimprovedinfants born prematureinfants born prematurelyinflamed bowelinflamed gutinflamed intestineintestinal inflammationintestinal microbesmicrobial consortiamicrobial floramicrobial imbalancemicrobiomemicrobiotamicrofloramultiorgan failuremultiple organ system failuremultispecies consortianatural hypothermianeonateneural inflammationneurodevelopmentneuroinflammationneuroinflammatorynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpathwaypediatric pharmacologyphase I protocolpreemptprematurepremature babypremature infant humanprematuritypreterm babypreterm infantpreterm infant humanpreventpreventingprobiotic therapeuticprobiotic therapyprobiotic treatmentprotective effectpupresilienceresilientresponsesocial roletranslation researchtranslational investigation
Description preview
SUMMARY: Worldwide, up to 25% of premature infants born prior to 31 weeks gestation, and up to 50% of
those born prior to 28 weeks gestation, have neurodevelopmental impairment (NI). The causes of NI are
multifactorial, but neuroinflammation is now recognized as a key component. Early life stresses commonly
encountered by premature infants,…
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