grant
A novel drug delivery system for the prevention and rescue of fentanyl and other opioid overdoses
Organization UNIVERSITY OF THE PACIFIC-STOCKTONLocation STOCKTON, UNITED STATESPosted 1 Apr 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20254-methoxycarbonyl fentanyl4-methoxycarbonylfentanylActiqAdderallAdderall XRAdverse effectsAmericanAntidotesArmed Forces PersonnelBBB crossingBBB penetrationBindingBlood SerumBrainBrain Nervous SystemBuprenorphineCessation of lifeCocaineCommon Rat StrainsCrystal MethCrystal methamphetamineDangerousnessDeathDeoxyephedrineDesoxyephedrineDevelopmentDiacetylmorphineDiamorphineDoseDrug DeliveryDrug Delivery SystemsDrug KineticsDrug PrecursorsDrugsDuragesicEncephalonEnsureEstersEvaluationFDA approvedFentanestFentanylFentylFundingGenerationsGoalsHappinessHepatic CellsHepatic Parenchymal CellHepatocyteHeroinHuman ResourcesHybridsHydrolysisHypodermisIllicit DrugsIn VitroInfumorphIngestionKadianLaw EnforcementLifeLigandsLiver CellsMS ContinMSirManpowerMedicationMetabolicMethamphetamineMethylamphetamineMilitaryMilitary PersonnelMolecular InteractionMonitorMorphiaMorphineN-MethylamphetamineNaloxoneNarcanNarcantiNuAlprazOpiate AntagonistOpiate receptor antagonistOpiatesOpioidOpioid AntagonistOpioid receptor antagonistOramorphOramorph SROverdosePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPercocetPersonsPharmaceutical PreparationsPharmacokineticsPhasePhentanylPrealbuminPrecipitationPreventionPro-DrugsProalbuminProdrugsPublic HealthRatRats MammalsRattusRenal clearance functionReportingRespirationRiskRoxanolSafetySchool-Age PopulationSeriesSerumSerum ProteinsStatex SRSubcutaneous TissueSubcutisSuperficial FasciaSystemTafilTela SubcutaneaTestingTheriacsTimeToxic effectToxicitiesTrankimazinTransthyretinUnited StatesWhole Body PlethysmographyWithdrawal SymptomXanaxabsorptionantagonismantagonistblood-brain barrier crossingblood-brain barrier penetrationbloodbrain barrier crossingbloodbrain barrier penetrationcarfentanilcarfentanyldesigndesigningdetermine efficacydevelopmentaldrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationefficacy testingevaluate efficacyexamine efficacyfentalogsfentaloguesfentanyl analogfentanyl overdosefirst responderhigh schoolhydrophilicityin vivoingestmass casualtymethmilitary populationmilligrammu opioid receptorsnalmefenenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyopiate crisisopiate deathsopiate mortalityopiate overdoseopiate related overdoseopiate use disorderopiate withdrawalopioid associated apneaopioid associated respiratory depressionopioid crisisopioid deathsopioid detoxopioid detoxificationopioid drug overdoseopioid epidemicopioid induced hypoventilationopioid induced overdoseopioid induced respiratory depressionopioid intoxicationopioid mediated respiratory depressionopioid medication overdoseopioid mortalityopioid overdoseopioid overdose deathopioid poisoningopioid related deathopioid related overdoseopioid related respiratory depressionopioid respiratory depressionopioid toxicityopioid use disorderopioid ventilatory depressionopioid withdrawaloverdose deathoverdose fatalitiespatient oriented outcomespersonnelpillprecipitationspreventpreventingrenal clearancerespiratory depression caused by opioidsrespiratory depression due to opioidsrespiratory mechanismschool ageside effectsubcutaneoussubdermalsubdermal tissuesynthetic opiatesynthetic opioidweaponsμ opioid receptorsμ-ORμOR
Description preview
Opioids have significant adverse effects highlighted by the large number of patients with opioid use disorder
(OUD) and the increasing number of overdose deaths in the United States and elsewhere. In just the 12-month
period ending in November 2021, more than 107,000 Americans died from drug overdose. Around 66% of these
deaths involved illicit…
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