grant
A non-invasive blood test for multi-cancer detection and determination of tissue of origin preceding overt cancer diagnosis
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 May 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2025AddressAgeAlgorithmsAssayBioassayBiological AssayBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood TestsBody TissuesBrain CancerCRC screeningCancer ControlCancer Control ScienceCancer DetectionCancersCell Communication and SignalingCell SignalingClinicalColon or RectumColorectalColorectal CancerCommunitiesDNADataDeoxyribonucleic AcidDiagnosisDiagnosticDiagnostic FindingsDifferential Gene ExpressionDiseaseDisorderDistant CancerDistant MetastasisEarly DiagnosisElasticityEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFaceFoundationsGastric Body CancerGastric CancerGastric Cardia CancerGastric Fundus CancerGastric Pylorus CancerGoalsHealthHealth ResourcesHematologic TestsHematological TestsHematology TestingHeparinHeparinic AcidHepatic CancerIndividualIntracellular Communication and SignalingKnowledgeLungLung Respiratory SystemMachine LearningMalignant Gastric NeoplasmMalignant Gastric TumorMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the BrainMalignant Tumor of the LungMalignant Tumor of the OvaryMalignant neoplasm of brainMalignant neoplasm of liverMalignant neoplasm of lungMalignant neoplasm of ovaryMalignant neoplasm of prostateMalignant prostatic tumorMapsMedicineModelingNGS MethodNGS systemOutcomeOvarianOvary CancerPLCO studyPLCO trialPathway interactionsPatient CompliancePerformancePhasePilot ProjectsPlasmaPlasma SerumPre-Clinical ModelPreclinical ModelsProstateProstate CAProstate CancerProstate GlandProstate malignancyProstate, Lung, Colo-rectal and Ovarian (PLCO) Cancer Screening TrialProstate, Lung, Colo-rectal and Ovarian Cancer (PLCO) screening trialProstate, Lung, Colo-rectal, and Ovarian (PLCO)Prostate, Lung, Colo-rectal, and Ovarian Cancer Screening TrialProstate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening TrialProstate, Lung, Colorectal and Ovarian Cancer (PLCO) screening trialProstate, Lung, Colorectal, and Ovarian (PLCO)Prostate, Lung, Colorectal, and Ovarian Cancer Screening TrialProstate, Lung, Ovarian (PLCO)Prostatic GlandProtocolProtocols documentationPulmonary CancerPulmonary malignant NeoplasmRaceRacesResearchResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRiskSamplingScreening for cancerSensitivity and SpecificitySignal TransductionSignal Transduction SystemsSignalingSigns and SymptomsSpecificityStomach CancerTestingTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTissuesTrainingTubeUnited StatesValidationadenomaagesalgorithm trainingbio-markersbiologic markerbiological signal transductionbiomarkerbiomarker discoverycancer carecancer classificationcancer diagnosiscancer statisticscancer typecell free DNAcell free DNA profilingcell free DNA screeningcell free DNA-based assaycell free circulating DNAcell-free DNA assaycell-free DNA testcfDNA assaycfDNA profilingcfDNA screeningcfDNA testcfDNA-based assayclinical diagnosiscolorectal cancer detectioncolorectal cancer early detectioncolorectal cancer screeningcolorectumdetect colorectal cancerdetection testdetection testsearly cancer detectionearly detectionepigenetic biomarkerepigenetic markerepigeneticallyfacesfacialgastric malignancygenome scalegenome wide analysisgenome wide studiesgenome-widegenome-wide analysisgenome-wide identificationgenomewideimprovedinterestliver cancerliver malignancylung cancermachine based learningmachine learning based modelmachine learning modelmalignancymalignant liver tumormalignant stomach neoplasmmalignant stomach tumorminimally invasivemortalitynanoneoplasm/cancernext gen sequencingnext generation sequencingnextgen sequencingovarian cancerpathwaypatient adherencepatient cooperationpilot studypre-clinicalpreclinicalprospectiveprostate, lung, colorectal and ovarian cancer screening cohortprostate, lung, colorectal, and ovarian cancer screeningracialracial backgroundracial originscreeningscreening cancer patientsscreening programscreeningssealsexstomach fundus cancerstomach pylorus cancertest using cell free DNAtests using cfDNAtooltumorvalidations
Description preview
PROJECT SUMMARY
In the United States, it is estimated there are ~730,000 new cases of prostate cancer, lung cancer, colorectal
cancer (CRC), and ovarian cancer annually. Advances in therapies during the past decades have significantly
improved clinical outcomes. For many common cancers, however, treatment options are limited when the
cancer is…
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