grant
A new therapeutic strategy to target liver metastasis in colon cancer
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026AbscissionAgonistAnimal ModelAnimal Models and Related StudiesAnimalsAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAssayAthymic MiceAthymic Nude MouseBALB C MouseBALB/cBindingBioassayBiological AssayBody TissuesCT-26CT26Cancer CauseCancer DrugCancer EtiologyCancer PatientCancersCause of DeathCell BodyCell IsolationCell LocomotionCell MigrationCell Migration InhibitionCell Migration Inhibition functionCell MovementCell SegregationCell SeparationCell Separation TechnologyCellsCellular MigrationCellular MotilityCessation of lifeChIP assayClinical TrialsColonColon CancerColon CarcinomaColon NeoplasmsColon TumorColonic MassColonic NeoplasmsColonic TumorD4DRDRD4DRD4 geneDataDeathDopamine Receptor D4Down-RegulationEMSAExcisionExperimental DesignsExtirpationFLT4FLT4 LigandFLT4 ProteinFLT4 geneFLT4-LFMS-Related Tyrosine Kinase 4Flt-4FrequenciesFutureG-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGoalsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHCT 116 CellsHCT- 116HCT-116HCT116HCT116 CellsHT-29HT-29 CellsHT29 CellsHepatic CellsHepatic Neoplasm SecondaryHepatic Parenchymal CellHepatic metastasisHepatocyteHistopathologyHumanImmunoblottingImmunocompetentInbred BALB C MiceIncidenceLigandsLiteratureLiverLiver CellsLiver secondariesLiver secondary cancerLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignant CellMalignant NeoplasmsMalignant TumorMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetastatic Neoplasm to the LiverMetastatic Tumor to the LiverMetastatic malignant neoplasm to liverMiceMice MammalsModern ManMolecularMolecular InteractionMurineMusNMR ImagingNMR TomographyNeoplastic Disease Chemotherapeutic AgentsNon-MalignantNuclear Magnetic Resonance ImagingNude MiceOperative ProceduresOperative Surgical ProceduresPathway interactionsPatientsPreventionPrimary NeoplasmPrimary TumorProcessReceptor ProteinRemovalReportingRoleSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalTCGAThe Cancer Genome AtlasTherapeutic EffectTimeTissuesTranslatingTransplantationTreatment EfficacyTripcellimTrypsinTumor-Specific Treatment AgentsTyrosine-Protein Kinase Receptor FLT4VEGFVEGF-CVEGFR-3VEGFR3VEGFsVGR3Vascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3Vascular Endothelial Growth Factor Related ProteinVascular Endothelial Growth FactorsWestern BlottingWestern ImmunoblottingZeugmatographyanti-canceranti-cancer drugcancer cellcancer in the coloncell motilitycell sortingchemotherapeutic agentchemotherapeutic compoundschemotherapeutic drugschemotherapeutic medicationschromatin immunoprecipitationcolon cancer patientscolon neoplasiacolorectal cancer patientscytokineeffective therapyeffective treatmentexperimentexperimental researchexperimental studyexperimentshepatic body systemhepatic organ systemimmune competentintervention efficacyknock-downknockdownliver metastaseslymph glandlymph nodeslymphnodesmalignancymalignant liver neoplasm, specified as secondarymetastasis in the livermetastasis to the livermetastasize to the livermetastatic cancer to livermetastatic livermetastatic liver neoplasmmigrationmodel of animalmutantneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnonmalignantnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpathwaypre-clinicalpreclinicalpreventpreventingprotein blottingreceptorresectionsecondary liver malignancysecondary malignant liver neoplasmsocial rolesurgerytherapeutic efficacytherapeutically effectivetherapy efficacytransplanttumor growth
Description preview
Colon cancer (CC) is one of the leading causes of cancer-related death in the world. Hepatic or liver
metastasis (LM) is the primary cause of death in colon cancer patients. Unfortunately, many CC patients
develop LM despite surgery with lymph node removal, and many die. Therefore, identifying novel
therapeutic approaches is necessary to prevent…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click