grant

A Neuropeptidergic Neural Network Integrates Taste with Internal State to Modulate Feeding

Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 8 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years oldAbdomenAddressAdultAdult HumanAffectAgricultureAnatomic SitesAnatomic structuresAnatomyAnimalsAnteriorAntidiabetic HormoneAppetiteAreaBehaviorBehavioralBrainBrain Nervous SystemCalciumCaloriesCell Communication and SignalingCell SignalingCognitive DiscriminationComplementComplement ProteinsD-GlucoseDataDecision MakingDesire for foodDextroseDigestionDiscriminationDiseaseDisease VectorsDisorderDiureticsDrosophilaDrosophila genusEncephalonEndocrine Gland SecretionEquilibriumEvaluationExposure toFeeding behaviorsFliesFoodFood PreferencesGlucagonGlucoseGlukagonGustationHG-FactorHealthHemolymphHormonesHornsHumanHungerHydrogen OxideHyperglycemic-Glycogenolytic FactorImageIngestionIngestive BehaviorInsect ControlInsectaInsectsInsects InvertebratesIntracellular Communication and SignalingIon TransportLabelLateralLocationMalnutritionMalpighian TubulesMammaliaMammalsMapsMetabolicMethodsModern ManMorbidityMorbidity - disease rateMushroom BodiesNerveNerve CellsNerve UnitNeural CellNeurocyteNeuromodulatorNeuronsNeuropeptidesNeuropilNutrientNutrition AssessmentNutritionalNutritional AssessmentNutritional DeficiencyObesityOrganPeptide TransportProcessPublishingReceptor ActivationReceptor ProteinRegulationResearchResolutionRoleSatiationShapesSignal TransductionSignal Transduction SystemsSignalingSiteSourceStereotyped BehaviorStereotypingStreamStructureSynapsesSynapticSystemTachykininTasteTaste PerceptionTechniquesTechnologyTestingTherapeutic HormoneToxinUndernutritionWateradipokinetic hormoneadiposityadulthoodanalogbalancebalance functionbiological signal transductioncomplementationconnectomecorpulencecorpus cardiacumdiet choicediet preferencedietary choicedietary deficiencydietary preferenceseat lessexperimentexperimental researchexperimental studyexperimentsfeedingfeeding-related behaviorsflyfood choicefood qualityfruit flygustatory perceptiongustatory processinggustatory responseimagingin vivoingestinterestmalnourishedmodel organismmutantneuralneural controlneural mechanismneural networkneural regulationneuromechanismneuromodulationneuromodulatoryneuronalneuropeptide Fneuroregulationnutrient intake activitynutrition deficiencynutrition deficiency disordernutritional deficiency disordernutritiouspost-synaptic nervespost-synaptic neuronspostsynaptic nervespostsynaptic neuronsreceptorreceptor expressionreduced eatingreduced food intakeresolutionsresponsesatietysocial rolesugarsynapsetaste processingtaste responsetool
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Description preview

Feeding is a fundamental behavior that is tightly regulated to precisely meet the metabolic needs of the animal.
The primary decision that an animal must make regarding food is whether to ingest it or reject it. Substances

with high nutritional value are ingested, while toxins and harmful substances are rejected. To make this decision,

the animal…

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A Neuropeptidergic Neural Network Integrates Taste with Internal State to Modulate Feeding — BROWN UNIVERSITY | UNITED S | Dev Procure