grant
A multimodal approach for immunotherapy of Staphylococcus aureus bacteremia
NIHUS FederalResearch GrantFY20257S Gamma GlobulinAb-mediated immunityAb-mediated protectionAblationAmanAnaphylactic ReactionAnaphylactic ShockAnaphylaxisAnimal ModelAnimal Models and Related StudiesAnti-Bacterial AgentsAntibiotic AgentsAntibiotic DrugsAntibioticsAntibodiesAntibody Binding SitesAntibody immunityAntibody protectionAntibody titer measurementAntibody-mediated protectionAntigenic DeterminantsAntigensAttenuatedAutolysinB blood cellsB cellB cell receptorB cellsB-Cell Antigen ReceptorB-CellsB-LymphocytesB-cellBacteremiaBacteriaBasophilic GranulocyteBasophilsBindingBinding DeterminantsBiologicalBiologyBlood BasophilBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood erythrocyteBlood monocyteCaviaCell AdhesionCell BodyCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell Surface AntigensCellsCellular AdhesionChromatographyClinicalClinical Treatment MoabCollaborationsComplementComplement ProteinsComplexContainmentCryo-electron MicroscopyCryoelectron MicroscopyCrystallographiesCrystallographyDendritic CellsDeuteriumDevelopmentDiseaseDisorderElectron CryomicroscopyEndotheliumEngineeringEnzyme GeneEnzymesEpitheliumEpitopesErythrocytesErythrocyticExposure toFe elementFoundationsGeneralized GrowthGlucosaminidaseGoalsGrowthGuinea PigsGuinea Pigs MammalsH elementH2 isotopeHMG-IHMGA1aHMGIHemalysinsHemolysinHistamine LiberationHistamine ReleaseHu-mABsHumanHydrogenIgEIgGImmuneImmune EvasionImmune mediated therapyImmune responseImmune systemImmunesImmunoglobulin EImmunoglobulin GImmunological Surface MarkersImmunologically Directed TherapyImmunologyImmunotherapeutic agentImmunotherapyInfectionInfectious Skin DiseasesIronLeadLeucocidinLifeMRSAMacacaMacaqueMacrophageMapsMarrow Mast CellMarrow NeutrophilMarrow erythrocyteMarrow monocyteMediatingMethicillin Resistant S. AureusMethodologyMiceMice MammalsMiscellaneous AntibioticModelingModern ManMolecular InteractionMonoclonal AntibodiesMorbidityMorbidity - disease rateMureinMurineMusMφNHP modelsNatureNeutrophilic GranulocyteNeutrophilic LeukocyteOperative ProceduresOperative Surgical ProceduresOutcomeParatopesPathogenicity FactorsPatientsPb elementPeptidoglycanPeriprosthetic joint infectionPersonsPhysiciansPneumoniaPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProductivityProteinsReceptor ProteinRecombinantsRed Blood CellsRed CellS aureusS aureus protein AS. aureusS. aureus infectionS. aureus protein ASepsisShapesSiteSoft Tissue InfectionsSortingStaph Protein AStaph aureusStaph aureus infectionStaph. Protein AStaphylococcal Protein AStaphylococcus aureusStaphylococcus aureus Protein AStaphylococcus aureus infectionStructureSuperantigensSurface AntigensSurgicalSurgical InterventionsSurgical ProcedureSurgical Wound InfectionT-CellsT-LymphocyteTestingTimeTissue BasophilsTissue GrowthToxic ShockToxic Shock SyndromeToxinUniversitiesVaccinationVaccinesVeiled CellsVirulenceVirulence Factorsaccess to vaccinationaccess to vaccinesanti-bacterialantibody combining siteantibody titeringantibody-mediated immunityattenuateattenuatesbacteraemiabacterial bloodstream infectionbacterial infection in the bloodstreambiologicbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesblood corpusclescell sortingclinical developmentcomplementationcrosslinkcryo-EMcryoEMcryogenic electron microscopycutaneous infectiondetermine efficacydevelopmentalefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationefficacy trialevaluate efficacyexamine efficacyexperienceguinea pig modelheavy metal Pbheavy metal leadhost responsehumAbshuman mAbshuman monoclonal antibodieshuman monoclonalshuman pathogenimmune drugsimmune evasiveimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunologic therapeuticsimmunopathologyimmunoresponseimmunotherapeuticsimmunotherapy agentimprovedinfected skininfected with S. aureusinfected with Staph aureusinfected with Staphylococcus aureuskeratinocytemAbsmast cellmastocytemethicillin resistance Staphylococcus aureusmethicillin resistant Staphylococcus aureusmethicillin resistant strains of Staphylococcus aureusmodel of animalmonoclonal Absmonocytemortalitymouse modelmulti-modalitymultimodalitymurine modelneutralizing antibodyneutrophilnon-human primatenonhuman primatenonhuman primate modelsnovelontogenypathogenprosthetic joint infectionprotective efficacyprotein protein interactionreceptorresponseskin infectionstructural biologysurgerysurgical site infectionthymus derived lymphocytevaccination accessvaccination availabilityvaccine accessvaccine availabilityvaccine candidate
Description preview
Staphylococcus aureus (S. aureus; SA) colonizes >50% of people and causes a wide range of diseases
including bacteremia, pneumonia, and surgical site infections. No SA vaccines or immunotherapeutics are
approved or in late-stage clinical development. Recent findings revealing the detrimental impact of prior
exposure to SA on shaping the immune…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click