grant
A multidisciplinary approach to understanding feedback and clustering in PCP signaling
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AortaArteriesAssayBindingBioassayBiochemicalBiologic ModelsBiological AssayBiological ModelsBirth DefectsBlood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesBudding YeastCadherinsCardiacCardiac DiseasesCardiac DisordersCardiac MalformationCardiac developmentCell BodyCell Communication and SignalingCell ComponentsCell JunctionsCell LocomotionCell MigrationCell MovementCell PolarityCell SignalingCell StructureCell divisionCell-Cell AdhesionCellsCellular MigrationCellular MotilityCellular StructuresCollaborationsComplexComputer ModelsComputerized ModelsCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCore ProteinCoupledDataDefectDevelopmentDictyosteliumDiseaseDisorderDissectionDistalDorsalDouble Outlet Right VentricleDrosophilaDrosophila genusDsh proteinEndomycetalesEpitheliumFeedbackFliesGenerationsGeneticGenetic studyHeartHeart DiseasesHeart MalformationHistoryHumanImageIndividualIntercellular JunctionsIntracellular Communication and SignalingKnowledgeLeft VentriclesLeft ventricular structureLipidsLogicMarrow NeutrophilMesenchymalMicroscopyModel SystemModern ManMolecularMolecular InteractionMorphogenesisNeural Tube DefectsNeural Tube Developmental DefectsNeutrophilic GranulocyteNeutrophilic LeukocyteOrangesOrganOrganismOutcomePathologyPathway interactionsPhysical condensationPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProcessPulmonary ArteryPulmonary artery structureRecording of previous eventsRight VentriclesRight ventricular structureRoleSaccharomycetalesScaffolding ProteinSeptateSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSitus InversusSystemTaussig-Bing AnomalyTechniquesTherapeutic InterventionTimeTissuesTranslatingTransposition of Great VesselsTubeVenousVertebrate AnimalsVertebratesWorkYeastsabnormal heart developmentatriumbiological signal transductionbiophysical analysisbiophysical approachesbiophysical methodologybiophysical methodsbiophysical studiesbiophysical techniquescardiogenesiscell motilitycellular polaritycomputational modelingcomputational modelscomputer based modelscomputerized modelingcondensationcongenital cardiac abnormalitycongenital cardiac anomaliescongenital cardiac diseasecongenital cardiac disordercongenital cardiac malformationcongenital heart abnormalitycongenital heart anomalycongenital heart diseasecongenital heart disordercongenital heart malformationconotruncal cardiac defectconotruncal defectconotruncal heart defectdeafnessdevelopmentaldishevelled proteinflyfruit flygene manipulationgenetic approachgenetic manipulationgenetic strategygenetically manipulategenetically perturbheart developmentheart disorderheart formationheterotaxia syndromeheterotaxyhigh definitionhigh-resolutionhistoriesimaginginsightintercalationinterdisciplinary approachintervention therapyinversion of visceralaterality sequenceliving systemlung developmentmigrationmolecular asymmetrymolecular scalemorphogenetic processmultidisciplinary approachnanodiskneutrophilnovelpathwayplanar cell polaritypolarized cellprospectivereconstitutereconstitutionsegregationsingle moleculesitus abnormalitysitus inversus viscerumsocial roletheoriestooltransposition of great arterytransposition of visceravertebratavisceral heterotaxyvisceral transposition
Description preview
Summary/Abstract
Planar cell polarity (PCP) signaling controls the polarization of cells within the plane of an epithelium, orienting
asymmetric cellular structures, cell divisions, and cell migration and is well conserved from Drosophila to
vertebrates. In vertebrates, defects in the core PCP mechanism result in a range of developmental anomalies…
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