grant
A multidisciplinary approach identifying PDZ-RhoGEF (ARHGEF11) as a critical regulator of synapses and cognition
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Apr 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20253' Untranslated Regions3'UTRAffectAttentionBindingBiochemicalBiological FunctionBiological ProcessBipolar Affective PsychosisBipolar DisorderBrainBrain Nervous SystemCell Communication and SignalingCell SignalingCerebral cortexCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalComplexDISC1DISC1 geneDT-RDTR geneDataDendritic SpinesDiphtheria Toxin Receptor (Heparin-Binding EGF-Like Growth Factor) GeneDiphtheria Toxin Receptor GeneDiphtheria Toxin Sensitivity GeneDiseaseDisorderDisrupted in Schizophrenia 1Disturbance in cognitionDown-RegulationDysfunctionElectrophysiologyElectrophysiology (science)EncephalonExhibitsExperimental DesignsFore-BrainForebrainFunctional disorderFutureGDP Dissociation FactorGDP Dissociation StimulatorsGDP Exchange FactorsGDP-GTP Exchange ProteinGDP-GTP Reversing FactorsGTP GDP exchange factorGWA studyGWASGene TargetingGene TransferGenesGliaGlial CellsGuanine Nucleotide Exchange FactorsGuanine Nucleotide Exchange ProteinGuanine Nucleotide Releasing FactorsGuanyl-Nucleotide Exchange FactorGuanyl-Nucleotide Releasing FactorHB-EGFHBEGFHEGFLHeparin-Binding EGF-Like Growth Factor GeneHumanHuman GenomeImageImpaired cognitionIndividualIntracellular Communication and SignalingInvestigationKolliker's reticulumLeadLearningLifeManic-Depressive PsychosisMediatingMemoryMental disordersMental health disordersMessenger RNAMethodsMiceMice MammalsMicroRNAsModern ManMolecularMolecular InteractionMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMurineMusNeocortexNerve CellsNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuronsNeurophysiology / ElectrophysiologyNon-neuronal cellNonneuronal cellOutcomePathway interactionsPb elementPhenotypePhysiologicPhysiologicalPhysiopathologyPopulationPrefrontal CortexProbabilityProsencephalonProteinsPsychiatric DiseasePsychiatric DisorderPublishingPyramidal neuronRISC Multicomponent NucleaseRNA purificationRNA-Induced Silencing ComplexRegulationRodentRodentiaRodents MammalsRoleSelection BiasSelection CriteriaSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmall G-ProteinsSmall GTPasesStructureSynapsesSynapticTestingTherapeuticTimeTwo HybridViralViral GenesVisualWorkYeast One Hybrid SystemYeast One/Two-Hybrid SystemYeastsbehavior phenotypebehavioral phenotypingbiological signal transductionbipolar affective disorderbipolar diseasebipolar illnessbipolar mood disorderbrain basedcognitive abilitycognitive defectscognitive dysfunctioncognitive functioncognitive losscohortdendrite spineelectrophysiologicalenzyme activityexchange factorgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studyheavy metal Pbheavy metal leadhippocampal pyramidal neuronhomotypical cortexhuman whole genomeimagingin silicointerdisciplinary approachinterestisocortexknock-downknockdownmRNAmanic depressive disordermanic depressive illnessmental illnessmiRNAmultidisciplinary approachneopalliumnerve cementneuralneuronalpathophysiologypathwaypsychiatric illnesspsychological disorderscaffoldscaffoldingsocial rolesuper high resolutionsuperresolutionsuperresolution imagingsynapsesynapse functionsynaptic functiontheoriestherapeutic targetultra high resolutionvirtualwhole genome association analysiswhole genome association studyyeast 2-hybridyeast two hybrid system
Description preview
PROJECT SUMMARY
Cognitive abilities have a profound impact on life outcomes. As such, there has been much scientific interest in
identifying genes that are critical for regulating cognitive phenotypes. The miR-132 microRNA is among the few
studied microRNAs that impacts learning and memory in rodents, is dysregulated in multiple human disorders…
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