grant
A multi-omic and integrative longitudinal evaluation of the role of lipid, antioxidant, and osmoprotectant metabolites in the genitourinary syndrome of menopause by race and ethnicity.
Organization MC LAUGHLIN RESEARCH INSTITUTELocation GREAT FALLS, UNITED STATESPosted 15 Jul 2023Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2026AD dementiaAdvocateAffectAgeAge related pathologiesAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAminoacetic AcidAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntioxidantsAssayAttenuatedAwardBioassayBiological AssayBiological MarkersBlood PlasmaBlood SerumCardiovascular DiseasesCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCaucasian FemalesCaucasian WomenCellular injuryCerebrospinal FluidChronicChronologyClinicalClinical DataCommunitiesComplexDataDevelopmentDiagnosisDiagnosticDiagnostic FindingsDietDisparateDoctor of PhilosophyDrynessEpidemiologyEpithelial CellsEstrogen TherapyEstrogensEthnic Minority WomenEthnic OriginEthnicityEvaluationExposure toFirst Generation College StudentsFirst Generation College graduatesFirst Generation StudentsGenitourinaryGenitourinary systemGleanGlutathioneGlycineGoalsGynecologicHealth Care CostsHealth CostsHumanImmunologyIn VitroInflammationInflammatory ResponseIntermediary MetabolismInterventionInvestigatorsItchingK-AwardsK-Series Research Career ProgramsKnowledgeLatinaLinkLipid PeroxidationLipidsLong-term cohortLongitudinal cohortLubricantsLubricationMachine LearningMediatingMediationMedicalMenopausal StatusMenopausal SyndromeMenopause SyndromeMentorsMetabolic ProcessesMetabolismMetabolite InteractionMethodsMicrobeMicrobiologyModalityModern ManModernizationMucosaMucosal TissueMucous MembraneNegotiatingNegotiationNon-HispanicNonhispanicNot Hispanic or LatinoOsmosisOsteoporosisOutcomeOxidative StressOxidative Stress InductionPainPainfulParticipantPathologyPh.D.PhDPhasePlasmaPlasma SerumPopulationPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePredispositionPreparationPreventionPrimary Senile Degenerative DementiaProcessPruritic DisorderPruritisPruritusPublicationsQOLQuality of lifeRaceRacesRecurrenceRecurrentResearchResearch Career ProgramResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRiskRoleSamplingScientific PublicationSerumSex FunctioningSexual HealthSexually Transmitted DiseasesSexually Transmitted DisorderSexually Transmitted InfectionSigns and SymptomsSphingolipidsStressStructural ModelsSusceptibilitySymptomsTherapeutic AgentsTherapeutic EstrogenUrogenitalUrogenital SystemVaginaValidationVenereal DiseasesVenereal DisordersVenereal InfectionsVitaminsWhite FemalesWhite WomenWomanWorkYouthYouth 10-21after menopauseage associatedage associated diseaseage associated disorderage associated impairmentage associated pathologiesage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage dependent pathologiesage induced pathologiesage linkedage relatedage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentagesaging associated pathologiesaging dependent pathologiesaging induced pathologiesaging pathologiesaging related pathologiesalleviate symptomameliorating symptomantioxidant therapyattenuateattenuatesbio-markersbiologic markerbiomarkercardiovascular disordercareercell damagecell injurycellular damagecerebral spinal fluidchildbearing agecohortcostcytokinedamage to cellsdecrease symptomdevelopmentaldietsearly experienceepidemiologicepidemiologicalestrogen disruptingestrogen disruptionestrogen hormone therapyestrogen treatmentestrogenic disruptionethnic minorityfat metabolismfertile agefewer symptomsfollowing menopausegamma-L-Glu-L-Cys-Glygamma-L-Glutamyl-L-Cysteinylglycinehigh riskimprovedinfection rateinjury to cellsinnovateinnovationinnovativeinsightitch sensationlipid metabolismmachine based learningmachine learning based methodmachine learning methodmachine learning methodologiesmarginalizationmetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmicrobial consortiamicrobial floramicrobial hostmicrobiomemicrobiotamicrofloramultiomicsmultiple omicsmultispecies consortianew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyolder adultolder adulthoodolder womenpanomicspast menopausepersonalized health interventionpersonalized interventionpost-doctoral trainingpost-menopausalpostmenopausalpostmenopausal statusprecision interventionspreparationsprimary degenerative dementiaracialracial backgroundracial minorityracial minority womenracial originrate of infectionreduce symptomsrelieves symptomsreproductivereproductive agereproductive yearssenile dementia of the Alzheimer typesexual functioningsexually acquired infectionside effectskillssocial rolesocial stigmaspinal fluidstatisticsstigmasymptom alleviationsymptom reductionsymptom relieftreated with estrogentreatment with estrogenvaginal floravaginal lactobacillivaginal microbial communityvaginal microbiotavaginal microfloravalidation studiesvalidationsyouth age
Description preview
The genitourinary syndrome of menopause (GSM) is an age-related chronic, progressive urogenital condition
that disproportionately affects postmenopausal women and contributes >$3 billion annually to US healthcare
costs. The impact of GSM is extensive and affects >62 million US women. Racial and ethnic minorities are
disproportionately affected but…
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