grant
A molecular toolbox for thermal control of programmed cell death in animals
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025Abscopal effectAddressAnimalsApoptosisApoptosis PathwayApoptosis-Related Cysteine Protease Caspase 1BALB C MouseBALB/cBilateralBiochemicalBody TissuesCASP-1CASP1CASP1 geneCT-26CT26Cancer TreatmentCaspaseCaspase GeneCaspase-1Caspase-1 GeneCell BodyCell Communication and SignalingCell DeathCell Death InductionCell LineCell ProtectionCell SignalingCell fusionCell-Death ProteaseCellLineCellsCessation of lifeChemicalsClinicColon CancerColon CarcinomaCoupledCustomCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesCytoprotectionCytotoxic ChemotherapyCytotoxic TherapyDeathDevicesDiseaseDisorderDoseElastinEngineeringEventFeedbackFoundationsFutureGoalsHealthHeatingHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHeterograftHeterologous TransplantationHumanICE ProteaseICE-like proteaseIL-1 beta ConvertaseIL-1 beta-Converting EnzymeIL-1BCIL-1b Converting EnzymeIL1B-ConvertaseIL1BCIL1BCEImageImmuneImmune systemImmunesImmunochemical ImmunologicImmunocompetentImmunologicImmunologicalImmunologicallyImmunologicsIn SituIn VitroInbred BALB C MiceIndividualInducer CellsInducer T-LymphocytesInflammationInterleukin 1-B Converting EnzymeInterleukin 1-Beta ConvertaseInterleukin-1 Beta Converting EnzymeInterleukin-1 Converting EnzymeIntracellular Communication and SignalingInvestigatorsLightLuciferase ImmunologicLuciferasesMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMammaliaMammalsMeasuresMessenger RNAMethodsMiceMice MammalsModern ManMolecularMurineMusOrganismPathway interactionsPenetrationPhotoradiationPhysical condensationPhysiologicPhysiologicalPhysiologyProgrammed Cell DeathProteinsRegulationRelaxationReportingResearch PersonnelResearchersSignal TransductionSignal Transduction SystemsSignalingSpecificityStimulusStrains Cell LinesSystemTechnologyTemperatureTestingTherapeuticTimeTissuesTranslationsTumor CellTumor PromotionWorkXenograftXenograft procedureXenotransplantationabscopal activityabscopal responseanimal tissueanti-cancer immunotherapyanti-cancer therapyanticancer immunotherapyapplied biomedical researchapplied biomedical sciencesbiological signal transductioncancer cellcancer immunotherapycancer in the coloncancer progressioncancer therapycancer-directed therapycell behaviorcell killingcell typecellular behaviorcondensationcultured cell linecustomscystein proteasecystein proteinasecysteine endopeptidasecytoprotectivehuman cancer mouse modelimagingimmune competentimmune-based cancer therapiesimmunogenicimmunogenic apoptosisimmunogenic cell deathimmunotherapy for cancerimmunotherapy of cancerin vivoindividualized cancer therapyindividualized cancer vaccineslipid based nanoparticlelipid nanoparticlelive cell imagelive cell imaginglive cellular imagelive cellular imagingliving systemmRNAmeltingmouse modelmurine modelnecrocytosisneoplasm progressionneoplastic cellneoplastic progressionnew approachesnew technologynovelnovel approachesnovel strategiesnovel strategynovel technologiesoptogeneticspathwaypersonalized anti-tumor vaccinespersonalized cancer therapypersonalized cancer treatmentpersonalized cancer vaccinespersonalized tumor vaccinespolypeptideprecision cancer vaccinesprogramsremote controlresponseself assemblyspatial and temporalspatial temporalspatiotemporalsuccesssystemic inflammationsystemic inflammatory responsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttechnology implementationtechnology validationtemporal measurementtemporal resolutiontime measurementtooltranslationtranslational applicationstranslational therapeuticstranslational therapytumortumor progressionxeno-transplantxeno-transplantation
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Summary/Abstract
The objective of this proposal is to develop a molecular toolbox for non-invasive methods to kill cells in situ via
specific cell death pathways using safe, penetrant, and tunable temperature stimuli. There is an urgent need
for new technology that can engage specific forms of cell death in vivo in a manner that is controlled in…
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