grant
A microphysiological model of prostate cancer metastasis into vascularized and innervated bone
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 26 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026AbscissionAccelerationAddressAdhesion MoleculeAdhesionsAdventitial CellAffectAnimal ModelAnimal Models and Related StudiesArchitectureAutomobile DrivingAutoregulationBiologic ModelsBiologicalBiological FunctionBiological ModelsBiological ProcessBlood VesselsBlood capillariesBone CancerBone MatrixBone MetastasisBone MineralizationBone ResorptionBone cancer metastaticBone remodelingBony metastasisCalcifiedCancer PatientCancersCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCellsCharacteristicsClinicalCommunicationDNADataDeoxyribonucleic AcidEndotheliumEngineeringEngineering / ArchitectureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumEventExcisionExhibitsExtirpationExtravasationFractureGametesGeneralized GrowthGeneticGenome InstabilityGenomic InstabilityGenomicsGerm CellsGerm-Line CellsGrantGrowthHomeostasisHumanImageInfiltrationInvadedKnowledgeLeadLeakageMalignant Bone NeoplasmMalignant NeoplasmsMalignant Osseous NeoplasmMalignant Osseous TumorMalignant TumorMalignant Tumor of the BoneMalignant neoplasm of prostateMalignant prostatic tumorMechanicsMediatingMediatorMetastasisMetastasis to boneMetastasizeMetastatic Cancer to the BoneMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the BoneMetastatic Prostate CancerMetastatic TumorMetastatic Tumor to the BoneMetastatic malignant neoplasm to boneModel SystemModelingModern ManModificationMolecularMolecular FingerprintingMolecular ProfilingNeoplasm Circulating CellsNeoplasm MetastasisNerveNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNuclearOrganOsseous CancerOsseous metastasisOsteoblastsOsteoclastic Bone LossOsteoclastsOsteocytesOsteolyticPainPainfulPathologicPathologic FracturePathological fracturePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPericapillary CellPericytesPerivascular CellPhenotypePhysiologicPhysiologic calcificationPhysiologicalPhysiological HomeostasisProstateProstate CAProstate CancerProstate Carcinoma MetastaticProstate GlandProstate malignancyProstatic GlandRegulationRemovalReproducibilityReproductive CellsResearchResolutionRouget CellsSecondary NeoplasmSecondary TumorSecondary cancer of boneSecondary malignancy of boneSecondary malignant neoplasm of boneSex CellSiteSkeletal metastasisSoilSpillageSpontaneous FracturesSurgical RemovalSystemTestingTimeTissue GrowthTropismTumor CellTumor PromotionUpregulationVascularizationVisualizationWorkadvanced prostate canceraxon signalingaxon-glial signalingaxonal signalingbalancebalance functionbiologicbonebone cellbone fracturebone growth factorbone neoplasm secondarycalcificationcancer metastasiscancer typecapillarycell adhesion proteinchip modelchip systemchronic paincirculating neoplastic cellcirculating tumor celldrivingepigeneticallyepigenomicsexperienceglia signalingglial signalingheavy metal Pbheavy metal leadhigh definitionhigh-resolutionimagingin vivoinitial cellinnervationinnovateinnovationinnovativeinsightmacrophage-derived osteoblast growth factormalignancymechanicmechanicalmetastatic processmicrophysiologic modelmicrophysiologic platformmicrophysiologic systemmicrophysiology modelmicrophysiology platformmicrophysiology systemmineralizationmodel of animalmolecular profilemolecular signaturenano meter scalenano meter sizednanometer scalenanometer sizednanoscaleneoplasm/cancerneoplastic cellnerve signalingnerve supplyneuralneural networkneural signalingneuronalneuronal signalingneuronal tumorneurotransmissionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targeton a chipon chipontogenyorgan chiporgan on a chiporgan on chippatient oriented outcomesprostate cancer cellprostate cancer metastasisprostate tumor cellrelease factorresectionresolutionsresponsesexual cellsingle cell analysisskeletalskeletal growth factortooltraffickingtumortumor cell metastasistumor growthvascular
Description preview
SUMMARY
Prostate cancer exhibits evident predilection for bone metastasis, occurring in over 80% of advanced cases and causing
serious skeletal complications. While organ-on-a-chip platforms have advanced metastasis research, existing
microphysiologic bone metastasis models fail to recapitulate critical microenvironmental features, particularly…
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