grant
A mechanistic trial of the neurobiology of extinction learning and intraparietal sulcus stimulation
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 15 Jan 2024Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY2025AddressArousalAttenuatedClinical TrialsCognitiveCuesDataDistressDoseDrugsEmotionalEvidence based practiceExpectancyExtinctionFailureFutureGoalsLeadLearningMeasuresMediatingMedicationNeurobiologyOutcomePTSDParietalParticipantPatient EducationPatient InstructionPatient TrainingPatientsPb elementPersonsPharmaceutical PreparationsPhysiologic pulsePopulationPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPsychotherapyPulseResearchResistanceRestRiskStartle ReactionStimulusSymptomsTestingTrainingTranscranial magnetic stimulationTranslatingTraumaUnited StatesVisitactive controlanalogattenuateattenuatesattenuationdesigndesigningdetermine efficacydrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyevidence baseexamine efficacyexperimentexperimental researchexperimental studyexperimentsfMRI scanfallsfunctional MRI scanfunctional magnetic resonance imaging scanheavy metal Pbheavy metal leadimprovedintraparietal sulcuslearning extinctionneuralneural controlneural mechanismneural regulationneurobiologicalneuromechanismneuromodulationneuromodulatoryneuroregulationnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpost-trauma stress disorderposttrauma stress disorderpreventpreventingrandomized controlled designresistantresponsestartle responsestemsynergismtraumatic neurosis
Description preview
Project Summary
Posttraumatic stress disorder (PTSD) is associated with alterations in arousal that do not respond well to
evidence-based practices. Patients with PTSD tend to fall into one of two groups in extinction training (and in
exposure therapy): 1) over-engagers, where arousal is too high; and 2) under-engagers, where patients are so…
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