grant
A Human iPSC-derived Microphysiological 3D model to study CAA/AD
Organization REGENERATIVE RESEARCH FOUNDATIONLocation Albany, UNITED STATESPosted 15 Feb 2026Deadline 14 Feb 2028
NIHUS FederalResearch GrantFY20263-D3-D modeling3-Dimensional3D3D modelingA β-42A β42A-beta 42A-beta42AD brainAD dementiaAD modelAD patientsAD riskAD risk factorAPOEAPOE e4APOE-ε4APOEε4Abeta-42Abeta42Acquired brain injuryAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's brainAlzheimer's disease brainAlzheimer's disease modelAlzheimer's disease patientAlzheimer's disease riskAlzheimer's patientAlzheimers DementiaAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid ProteinsAmyloid SubstanceAmyloid beta-42Amyloid beta-ProteinAmyloid beta42Amyloid depositionAmyloid βAmyloid β-42Amyloid β-PeptideAmyloid β-ProteinAmyloid β42Amyloidβ-42Amyloidβ42Apo-EApoE proteinApolipoprotein EAttenuatedAβAβ-42Aβ42B cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Beta Proprotein Interleukin 1BleedingBloodBlood - brain barrier anatomyBlood PlasmaBlood Reticuloendothelial SystemBlood SerumBlood VesselsBlood flowBlood monocyteBlood-Brain BarrierBrainBrain EdemaBrain InjuriesBrain Nervous SystemBrain SwellingBrain Vascular DisordersCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell LineCell SignalingCell-to-Cell InteractionCellLineCellsCerebral Amyloid AngiopathyCerebral Brain HemorrhageCerebral HemorrhageCerebral Parenchymal HemorrhageCerebral hemisphere hemorrhageCerebrovascular DiseaseCerebrovascular DisordersCerebrum HemorrhageCollectionComplexCongophilic AngiopathyDataData SetDepositDepositionDevelopmentDextransDiffusionDiseaseDisorderEncephalonEndothelial CellsEndotheliumEnvironmental FactorEnvironmental Risk FactorEventExposure toFibrinFutureGene ExpressionGeneticGenetic predisposing factorGenetic studyGenotypeHPGFHemato-Encephalic BarrierHematopoieticHemorrhageHepatocyte-Stimulating FactorHortega cellHumanHybridoma Growth FactorIFN-beta 2IFNB2IL-1 betaIL-1 βIL-1-bIL-1βIL-6IL1-BetaIL1-βIL1B ProteinIL1F2IL1βIL6 ProteinImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodInflammationInflammatoryInterleukin 1betaInterleukin-1 betaInterleukin-1βInterleukin-6Intracellular Communication and SignalingIntracerebral HemorrhageIntracranial EdemaIntracranial Vascular DiseasesIntracranial Vascular DisordersLabelLinkMGI-2MacrophageMarrow monocyteMeasuresMicrofluidic DeviceMicrofluidic Lab-On-A-ChipMicrofluidic MicrochipsMicrogliaModelingModern ManMolecularMonitorMorphologyMyeloid Differentiation-Inducing ProteinMφNerve DegenerationNeuron DegenerationNuclear RNAPathologyPatientsPeptidesPerfusionPhagocytosisPhenotypePhysiologicPhysiologicalPlasmaPlasma SerumPlasmacytoma Growth FactorPreinterleukin 1 BetaPrimary Senile Degenerative DementiaProductionPublishingRNA SeqRNA sequencingRNAseqReporterReticuloendothelial System, Serum, PlasmaRiboTagSTAT3STAT3 geneSerumSideSignal TransductionSignal Transduction SystemsSignalingStrains Cell LinesStructureSymptomsTechnologyTestingTimeTranslatingVascular DiseasesVascular DisorderVascular Endothelial CellVasculogenicWorka beta peptideabetaagedalzheimer modelalzheimer riskamyloid angiopathyamyloid betaamyloid-b proteinapo E-4apo E4apo epsilon4apoE epsilon 4apoE-4apoE4apolipoprotein E epsilon 4apolipoprotein E-4apolipoprotein E4attenuateattenuatesbeta amyloid fibrilbiological signal transductionblood lossblood vessel disorderbloodbrain barrierbrain controlbrain damagebrain vascular diseasebrain vascular dysfunctionbrain-injuredcell typecerebral vascular diseasecerebral vascular dysfunctioncerebrovascular amyloidosiscerebrovascular dysfunctioncultured cell linecytokinedevelopmentaldextrandiffuseddiffusesdiffusingdiffusionsdisease modeldisorder modelenhancing factorenvironmental riskgenetic risk assessmentgenetic risk factorgitter cellglial vascularglial vasculaturegliovasculargliovasculatureglobal gene expressionglobal transcription profilehemopoietichiPSChigh riskhuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman progenitor cell derivedhuman stem cell-derivedhydrogel scaffoldiPSiPSCiPSCsimprovedin vivoinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinherited factorinterferon beta 2intracranial vascular dysfunctionmesogliamicrofluidic chipmicroglial cellmicrogliocytemodel buildingmonocytemouse modelmurine modelneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnovelpatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepatients with ADperivascular glial cellprimary degenerative dementiaprogenitor cell modelprogenitor modelprotective effectresponserisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk of developing Alzheimer'ssenile dementia of the Alzheimer typesoluble amyloid precursor proteinstem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelthree dimensionalthree-dimensional modelingtranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicsvascularvascular amyloid accumulationvascular amyloid build upvascular amyloid depositionvascular amyloid depositsvascular amyloid pathologyvascular amyloidosisvascular dysfunctionvascular inflammationvasculopathywet brain
Description preview
Summary/Abstract
Vascular pathology has been identified as a critical driver of Alzheimer’s disease. This proposal aims to establish
a human induced pluripotent stem cell (iPSC)-derived model to study the impact of genetic and environmental
factors on the development of Alzheimer’s disease-related vascular pathology. Most Alzheimer’s disease…
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