grant
A gut sense for dietary lysine
NIHUS FederalResearch GrantFY20265-HT5-Hydroxytryptamine5HTAffectAffinityAmino AcidsAnimalsAutoregulationBasic Amino Acid Transport ProteinsBasic Amino Acid Transport SystemsBasic Fibroblast Growth FactorBasic Fibroblast Growth Factor GeneBehaviorBiologyBrainBrain Nervous SystemCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCarrier ProteinsCas nuclease technologyCationic Amino Acid Transport ProteinsCationic Amino Acid Transport SystemsCationic Amino Acid TransportersCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsCessation of lifeClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyConsumptionCranial Nerve XDataDeathDetectionDietDietary ProteinsDuodenumEatingEating BehaviorEncephalonEnteramineEquilibriumEssential Amino AcidsEsthesiaExposure toFGF-2FGF2FGF2 geneFGFBFeeding behaviorsFibroblast Growth Factor 2Fibroblast Growth Factor 2 GeneFood IntakeFood PreferencesFoundationsFutureGLP-1Generalized GrowthGenesGestationGlp-1GlutamatesGoalsGrowthGut EpitheliumHBGF-2Heparin-Binding Growth Factor 2Heparin-Binding Growth Factor Class IIHippophaineHomeostasisImpairmentIngestionIngestive BehaviorIntestinalIntestinesIntracellular Communication and SignalingKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeL-GlutamateL-LysineLaboratoriesLesionLifeLinkLysineMacronutrientsMacronutrients NutritionMalnutritionMediatingMembrane Transport ProteinsMembrane TransportersMetabolicMiceMice MammalsModelingMurineMusNerveNerve Impulse TransmissionNerve TransmissionNerve Transmitter SubstancesNeuroendocrineNeuroendocrine SystemNeuronal TransmissionNeurosecretory SystemsNeurotransmittersNull MouseNutrientNutritionalNutritional DeficiencyObesityOrganoidsPartner in relationshipPhysiologicPhysiologicalPhysiological HomeostasisPneumogastric NervePregnancyProstate Epithelial Cell Growth FactorProtein BiosynthesisProtein DeficiencyProteinsR-Series Research ProjectsR01 MechanismR01 ProgramReceptor ProteinRegulationResearchResearch GrantsResearch Project GrantsResearch ProjectsRewardsRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisSensationSensorySerotoninSignal PathwaySignal TransductionSignal Transduction PathwaySignal Transduction SystemsSignalingSiteSpecialized Epithelial CellStrains Cell LinesSynapsesSynapticTaste BudsTenth Cranial NerveTestingTherapeuticTissue GrowthTranscriptTransport Protein GeneTransport ProteinsTransporter ProteinUndernutritionVagus NerveVagus nerve structureWeaningWild Type MouseWorkadiposityafferent nerveaminoacidaxon signalingaxon-glial signalingaxonal signalingbFGFbalancebalance functionbehavior changebehavior phenotypebehavioral phenotypingbiological signal transductionbody sensebowelcorpulencecultured cell linedeficiency of proteindiet choicediet preferencedietarydietary choicedietary deficiencydietary preferencesdietsexperienceexperimentexperimental researchexperimental studyexperimentsfeeding-related behaviorsfood Ingestionfood choicefood consumptiongastrointestinal epitheliumglia signalingglial signalingglucagon-like peptide 1glutamatergicgut to brain axisgut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalingingestinhibitorintestinal epitheliummalnourishedmatenerve signalingneural circuitneural circuitryneural signalingneurocircuitryneuronal signalingneurotransmissionnew approachesnovel approachesnovel strategiesnovel strategynutrient intake activitynutrition deficiencynutrition deficiency disordernutritional deficiency disordernutritiousontogenyoptogeneticspreferencepreservationpreventpreventingprotein intakeprotein synthesisreceptorresponsesensory nervesugarsynapsesynaptic circuitsynaptic circuitrytaste receptorwildtype mouse
Description preview
SUMMARY
As an essential amino acid, lysine is necessary for life. Accordingly, when exposed to a lysine-deficient diet,
animals will seek out dietary lysine1. However, when animals are lysine-replete, lysine administration is a
powerful inhibitor of overall food intake2. Despite this fine-tuned regulation of overall food consumption based
on…
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