grant
A genetically encoded toolset to decipher the biology of post-translational modifications in the mammalian proteome
Organization BOSTON COLLEGELocation CHESTNUT HILL, UNITED STATESPosted 1 May 2020Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AcetylationAddressAmino AcidsArginineAutoimmune DiseasesBiochemicalBiologyBody TissuesCancersCell BodyCellsChemicalsComplexDirected Molecular EvolutionDiseaseDisorderDizzinessEngineeringEukaryotaEukaryoteEukaryotic CellGenetic CodeGenetics-MutagenesisGlnGlutamineHealthHumanIn VitroKnowledgeL-ArginineL-GlutamineL-LysineLabelLysineMalignant NeoplasmsMalignant TumorMammalian CellMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMethylationModelingModern ManModificationMolecular ConfigurationMolecular ConformationMolecular StereochemistryMutagenesisMutagenesis Molecular BiologyPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPropertyProtein ModificationProteinsProteomeProteomicsQ LevoglutamideQ. LevoglutamideResearchRoleSiteSpeedSystemTechnologyTissuesTransfectionTyrosine Phosphorylationaminoacidautoimmune conditionautoimmune disorderautoimmunity diseaseconformationconformationalconformational stateconformationallyconformationsdelivery vectordelivery vehicledirected evolutionimmunogenicityimprovedmalignancyneoplasm/cancernew approachesnovelnovel approachesnovel strategiesnovel strategyreconstitutereconstitutionsingle-molecule FRETsingle-molecule fluorescence resonance energy transfersmFRETsocial rolesulfotyrosinetyrosine O-sulfatetyrosine sulfatevirtual
Description preview
Project Abstract
Post-translational modifications (PTMs) dramatically expand the chemical and functional space accessible
to proteins. Over the last 25 years, the landscape of known PTMs within the mammalian proteome has
expanded at a dizzying speed, driven by the remarkable advances in mass-spectrometry based proteomics.
However, functional…
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