grant
A Forward Genetic Screen to Identify Genes Involved in Amphetamine Action
Organization FLORIDA ATLANTIC UNIVERSITYLocation BOCA RATON, UNITED STATESPosted 15 May 2025Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025AD/HDADHDAcuteAdderallAdderall XRAffectAmphetaminesAnimalsAnorexiaAssayAttention deficit hyperactivity disorderAttenuatedAutomobile DrivingBehaviorBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioralBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBioassayBiological AssayBrainBrain Nervous SystemC elegansC. elegansC.elegansCaenorhabditis elegansCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell Communication and SignalingCell SignalingChronicCodeCoding SystemCollectionConditioning TherapyCrystal MethCrystal methamphetamineDA NeuronDAT dopamine transporterDNA mutationDataData BasesDatabasesDeoxyephedrineDesoxyephedrineDesoxynorephedrinDopamineDopamine ReceptorDopamine neuronDrugsEncephalonExhibitsFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2GenesGeneticGenetic ChangeGenetic ScreeningGenetic defectGenetic mutationHeart VascularHumanHydroxytyramineIndividualInsomniaInsomnia DisorderIntracellular Communication and SignalingInvestigationKnock-outKnockoutLeadLearningMapsMechanistic Target of RapamycinMediatingMedicationMethamphetamineMethodologyMethylamphetamineModern ManMutateMutationN-MethylamphetamineNamesNematodaNematodesNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologic DisordersNeurological DisordersNeuronsOrganismOrthologOrthologous GeneOverdosePalsyParalysedPathway interactionsPb elementPersonsPharmaceutical PreparationsPhenaminePhenoprominPhenotypePhysiologicPhysiologicalPlegiaPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderProteinsPublishingRAFT1Receptor ProteinResearchSEQ-ANSequence AnalysesSequence AnalysisSignal TransductionSignal Transduction SystemsSignalingSleeplessnessSubstance Use DisorderSwimmingSynapsesSynapticSystemTestingTimeTrainingTransmissionTyrosine 3-MonooxygenaseTyrosine HydroxylaseUnderrepresented Ethnic MinorityUnderrepresented MinorityUnited StatesWorkabused drugabused drugsaddictionaddiction liabilityaddiction potentialaddictive disorderattenuateattenuatesbehavior interventionbehavioral interventionbiological signal transductioncartilage link proteincirculatory systemcollege studentdata basedesigndesigningdl-Amphetaminedopamine transporterdopaminergic neurondrivingdrug abuseddrug of abusedrug/agentdrugs abuseddrugs of abuseextracellulargene functiongenome mutationheavy metal Pbheavy metal leadin vivoinsightknock-downknockdownlink proteinliving systemmTORmammalian target of rapamycinmethmonoamine vesicular transport proteinsmutantnamenamednamingneurological diseaseneuronalnovelparalysisparalyticpathwaypharmacologicpostsynapticpsychostimulant abusereceptorrecruitresponseroundwormscreeningscreeningsside effectstimulant abusesubstance use and disordersubstance use treatmentsynapsetooltransmission processunder-representation of minoritiesunder-represented minorityundergradundergraduateundergraduate studentunderrepresentation of minoritiesuniversity studentvesicular monoamine transporter
Description preview
Project Summary
Amphetamine (Amph) and Amph-like drugs are commonly abused psychostimulants that come
with a high addiction liability. Numerous studies have shown that Amph alters the function of
various proteins in the brain. Among others, proteins linked to dopamine signaling are major
targets of Amph. However, despite decades of active…
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