grant
A Dynamic Diversity of Dopamine Neurons
Organization LSU HEALTH SCIENCES CENTERLocation NEW ORLEANS, UNITED STATESPosted 1 Apr 2017Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AffectAnesthesiaAnesthesia proceduresAntimorphic mutationAssociation LearningAssociative LearningAxonBasal GangliaBasal NucleiBehaviorBindingBiophysical ProcessCategoriesCell Communication and SignalingCell SignalingClampingsClosure by clampComputer ModelsComputerized ModelsCorpus StriatumCorpus striatum structureDA NeuronDataDendritesDialysisDialysis procedureDiseaseDisinhibitionDisorderDistalDominant NegativeDominant-Negative MutantDominant-Negative MutationDopamineDopamine neuronElectrophysiologyElectrophysiology (science)ExhibitsFGF-13FGF13FrequenciesGenerationsHeadHydroxytyramineImpairmentIn VitroInterruptionInterventionIntracellular Communication and SignalingIon ChannelIonic ChannelsKv4 channelLateralLearningMathMathematicsMedialMembrane ChannelsMesencephalonMiceMice MammalsMid-brainMidbrainMidbrain structureModelingMolecularMolecular InteractionMorphologyMotivationMovementMurineMusMuscarinic AgonistsMuscarinic Cholinergic AgonistsNasalNasal Passages NoseNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNon-linear DynamicNon-linear DynamicsNonlinear DynamicNonlinear DynamicsNoseNucleus AccumbensPace StimulatorsPacemakersParalysis AgitansParkinsonParkinson DiseasePatternPavlovian conditioningPeptidesPhasePhenotypePopulationPrimary ParkinsonismPropertyRampRespiratory System, Nose, Nasal PassagesRewardsRoleSchizophreniaSchizophrenic DisordersShapesShort interfering RNASignal TransductionSignal Transduction SystemsSignalingSmall Interfering RNAStriate BodyStriatumSubstance abuse problemSubstantia NigraSubstantia nigra structureSynapsesSynapticTestingTimeabuse of substancesassociative conditioningbiological signal transductionbiophysical mechanismbody movementcholinergicclassical conditioningcomputational modelingcomputational modelscomputer based modelscomputerized modelingdementia praecoxdialysis therapydopaminergic neuronelectrophysiologicalexpectationexperimentexperimental researchexperimental studyexperimentsextracellularfibroblast growth factor 13gene manipulationgenetic manipulationgenetically manipulategenetically perturbin vivoinhibitorinsightknock-downknockdownmarkov modelmotivated behaviorneuronalpatch clamppharmacologicpopulation basedresponseschizophrenicsequence learningsiRNAsocial rolestriatalsubstance abusesynapsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentvirtual
Description preview
We aim to understand the biophysical mechanisms that enable the distinct intrinsic dynamics of projection-
defined dopamine (DA) neuron subpopulations by a combination of modeling and in vivo/in vitro experimental
strategies. We focus on how intrinsic dynamics differ between defined DA subpopulations, and how those
differences shape the…
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