grant
A Contrast-free Ultrasound-based Quantitative Angio Flow Imaging Technique to Assess Peripheral Arterial Disease of Lower Limb
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AmputationAnatomic SitesAnatomic structuresAnatomyAnkleArteriesBiological MarkersBiomedical EngineeringBlood VesselsBlood flowCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell Communication and SignalingCell SignalingChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicClinicalClinical ResearchClinical StudyClutteringsCollaborationsComplementComplement ProteinsContrast AgentContrast DrugsContrast MediaDataDevelopmentDiabetes MellitusDiagnosisDiagnosticDiseaseDisease ProgressionDisorderEarly DiagnosisEarly treatmentElderlyEndotheliumEnvironmentEventExerciseGoalsGroups at riskHeart VascularImageImaging DeviceImaging InstrumentImaging ProceduresImaging TechnicsImaging TechniquesImaging ToolImpairmentInjectionsInterventionIntracellular Communication and SignalingInvestigatorsLegLower ExtremityLower LimbMeasurementMeasuresMembrum inferiusMethodsMicrocirculationMonitorMuscleMuscle TissueNamesNoisePathological ConstrictionPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPeople at riskPeripheralPeripheral arterial diseasePersons at riskPhysiciansPlayPopulations at RiskPrevalenceRadiopaque MediaRecurrenceRecurrentRegio tarsalisRegulationResearchResearch PersonnelResearchersRiskRoleSensitivity and SpecificitySightSignal TransductionSignal Transduction SystemsSignalingStenosisStimulusSymptomsSyndromeTechniquesTechnologyTimeTranslatingVariantVariationVascular DiseasesVascular DisorderVisionadvanced agebio-engineeredbio-engineersbio-markersbioengineeringbiologic markerbiological engineeringbiological signal transductionbiomarkerblood vessel disorderchronic kidney diseasecirculatory systemclaudicationclinical practicecohortcomplementationcostdetermine efficacydevelopmentaldiabetesdiagnostic tooldisabilityearly detectionearly therapyefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyexercise intoleranceexperiencegeriatrichigh resolution imagingimage-based methodimagingimaging biomarkerimaging markerimaging methodimaging modalityimaging-based biological markerimaging-based biomarkerimaging-based markerin vivoindexinginnovateinnovationinnovativemuscularnamenamednamingnew technologynovelnovel imaging technologynovel technologiespatient oriented outcomespatient oriented researchpatient oriented studypatient populationperipheral artery diseaseportabilitypressurepublic health relevancequantitative imagingresponseresponse to therapyresponse to treatmentscreeningscreeningssenior citizensocial rolestandard of caretherapeutic responsetherapy responsetooltreatment responsetreatment responsivenessultrasoundvascularvascular dysfunctionvasculopathyvisual functionvolunteer
Description preview
Abstract/Summary
PAD is characterized by impaired blood flow to the lower extremities, causing claudication and exercise
intolerance. Up to now, assessment of PAD is mainly performed by determination of stenosis or occlusion in
the large arteries and does not focus on microcirculation. Impaired arteriolar endothelial function,
microvascular…
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