grant
A comprehensive study of sequence variation effects on PCNA function.
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 7 Jul 2025Deadline 6 Jul 2029
NIHUS FederalResearch GrantFY2025AddressAffectAmino AcidsAnti-Cancer AgentsAntigen PresentationAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAssayBindingBioassayBiochemicalBiological AssayCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCalorimetryCancer DrugCancersCas nuclease technologyCell BodyCell CycleCell Cycle CheckpointCell Cycle ControlCell Cycle RegulationCell Division CycleCell FunctionCell Growth in NumberCell LineCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCell SurvivalCell ViabilityCellLineCellsCellular ExpansionCellular FunctionCellular GrowthCellular PhysiologyCellular ProcessCellular ProliferationCharacteristicsChemicalsClampingsClinicalClosure by clampClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexConserved SequenceDNADNA DamageDNA Damage RepairDNA InjuryDNA Polymerase Delta Auxiliary ProteinDNA PolymerasesDNA RepairDNA Repair DeficiencyDNA Repair DisorderDNA ReplicationDNA SynthesisDNA biosynthesisDNA mutationDNA-Dependent DNA PolymerasesDNA-Directed DNA PolymeraseDataDefectDeoxyribonucleic AcidDevelopmentDiseaseDisease ManagementDisorderDisorder ManagementDysfunctionEarly InterventionEnvironmentEquipmentEukaryotaEukaryoteEvolutionExhibitsExposure toFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional disorderGeneralized GrowthGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenome StabilityGenomic StabilityGerm-Line MutationGrowthHereditary MutationHumanIndividualLeadLifeLinkLocationMalignant CellMalignant NeoplasmsMalignant Skin NeoplasmMalignant TumorModern ManMolecular InteractionMutateMutationNeoplastic Disease Chemotherapeutic AgentsNerve DegenerationNeuron DegenerationOnset of illnessOrganismOuter pigmented layer of retinaPCNA-CyclinPathogenicityPathway interactionsPatientsPb elementPhysiciansPhysiopathologyPigment cell layer of retinaPigmented layer of retinaPlayPoint MutationPredispositionPremature AgingPremature aging syndromePreventative carePreventative treatmentPreventive MedicinePreventive carePreventive treatmentProcessProliferatingProliferating Cell Nuclear AntigenProteinsPublic HealthRegulationReportingReproductionResearch ResourcesResourcesRetinal Pigment EpitheliumRetinal pigment epithelial cellsShapesSkin CancerSkin developmentSlideSomatic MutationStrains Cell LinesStructureStructure of retinal pigment epitheliumSubcellular ProcessSusceptibilityTechniquesTestingTherapeuticTissue GrowthTitrationsTumor-Specific Treatment AgentsUV sensitiveUV sensitivityUnscheduled DNA SynthesisVariantVariationWorkYeastsaminoacidanti-cancer druganti-cancer researchataxia-telangiectasia like disordercancer cellcancer diagnosiscancer progressioncancer researchcell behaviorcell cycle check pointcell growthcellular behaviorcultured cell linedesigndesigningdevelopmentaldisease onsetdisorder onsetdrug developmentestablished cell linefitnessflow cytophotometrygene conservationgenome integritygenome mutationgenomic integritygerm-line defectgermline variantheavy metal Pbheavy metal leadinsightliving systemmalignancymalignant skin tumormutantmutation scanningmutation screeningneoplasm progressionneoplasm/cancerneoplastic progressionneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationontogenypathophysiologypathwaypreventative medicineprotein functionresponseskills trainingskin organogenesissomatic varianttherapeutic agent developmenttherapeutic developmentthermolabilitythermostabilitytumor progressionvirtual
Description preview
Project Summary
Mutations in genes encoding proteins that are essential for cell processes such as DNA replication can lead to
cellular dysfunction and disease. Protein defects can perturb these cell processes by removing or surpassing
cell cycle checkpoints, leading to errant growth and proliferation of cells, defining characteristics of cancer.…
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