grant
A CHOLINERGIC NEUROCIRCUIT REGULATES FEEDING BEHAVIOR
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 1 Jun 2024Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025AblationAcetylcholineAgonistAmericanAmmon HornAutoregulationBody WeightBrainBrain Nervous SystemBrain regionCOVID-19CV-19Caloric IntakeCancersCardiovascular DiseasesCell BodyCellsChronicComplexCornu AmmonisCoronavirus Infectious Disease 2019DataDevelopmentDiabetes MellitusDiagonal Band of BrocaEatingElectrophysiologyElectrophysiology (science)EncephalonEnergy ExpenditureEnergy IntakeEnergy MetabolismEquilibriumFeeding behaviorsFiberFoodFood IntakeFood Intake RegulationFutureGeneticGoalsHippocampal FormationHippocampusHomeostasisHypothalamic structureHypothalamusIngestive BehaviorIon Channel GatingIon Channel GatingsKnowledgeLateralLigandsMalignant NeoplasmsMalignant TumorMediatingMedicalMental DepressionMiceMice MammalsModelingMurineMusNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNeurotransmittersNicotinic Acetylcholine ReceptorsNicotinic ReceptorsNucleus AccumbensObesityOutcomeOutputOver weightOverweightPhotometryPhysiologicPhysiologicalPhysiological HomeostasisReceptor SignalingRegulationResearchRisk FactorsRoleSynapsesSynapticTestingViral VectorWeightWeight maintenance regimenadiposityalpha-bungarotoxin binding sitesalpha-bungarotoxin receptoralpha7 nicotinic acetylcholine receptoralpha7nAChRbalancebalance functionbasal forebraincaloric dietary contentcardiovascular disordercell typecholinergiccholinergic neuronco-morbidco-morbiditycombatcomorbiditycoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19corpulencedepressiondevelopmentaldiabetesdiabetes riskeating cueselectrophysiologicalenergy balancefeedingfeeding-related behaviorsfood cuesgene manipulationgenetic approachgenetic manipulationgenetic strategygenetically manipulategenetically perturbglobal healthhippocampalhunger cueshypothalamicmalignancymouse modelmurine modelneoplasm/cancerneural circuitneural circuitryneural networkneurobiological mechanismneurocircuitryneuronalnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachnutrient intake activityobese individualsobese peopleobese personobese populationobese subjectsobesity developmentobesity interventionobesity preventionobesity therapyobesity treatmentprevent obesityreceptor functionsocial rolesynapsesynaptic circuitsynaptic circuitrytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentweight controlweight managementweightsα7 nicotinic acetylcholine receptorα7nAChR
Description preview
PROJECT SUMMARY
Obesity is a major risk factor for many chronic medical conditions, including diabetes, cardiovascular disease,
depression, and cancer. Elucidating the neural networks that regulate feeding behavior and body weight control
is critically needed towards the development of effective strategies to combat obesity and its co-morbidities.…
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