grant
A Cereblon signaling network in Wnt-driven cancers
NIHUS FederalResearch GrantFY2026AnimalsApoptosisApoptosis PathwayAttenuatedBeta Cadherin-Associated ProteinBeta-1 CateninBindingBinding ProteinsBiochemicalBiological MarkersBrachydanio rerioBypassCUL-2Cancer CauseCancer EtiologyCancer ModelCancerModelCancersCause of DeathCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsCellular ExpansionCellular GrowthCessation of lifeCharacteristicsClinicalClinical TrialsColonColorectal CancerComplexCultured CellsDNA mutationDanio rerioDataData SetDeathDevelopmentDiseaseDisorderDrosophilaDrosophila genusDrug TargetingDrugsE3 LigaseE3 Ubiquitin LigaseEngineeringFDA approvedFDA licensed drugsFDA-approved agentsFDA-approved drugFDA-approved medicationsFDA-approved pharmaceuticalsFDA-approved therapeutic agentFood and Drug Administration approved drugFood and Drug Administration approved medicationsFood and Drug Administration approved pharmaceuticalsGI Stem cellGeneralized GrowthGenetic ChangeGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic defectGenetic mutationGoalsGrowthHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHeterograftHeterologous TransplantationHumanHuman EngineeringImplantIn VitroIntestinalIntestinesIntracellular Communication and SignalingKnowledgeLigand Binding ProteinLigand Binding Protein GeneMalignant CellMalignant Hematologic NeoplasmMalignant NeoplasmsMalignant TumorMeasuresMedicationMiceMice MammalsModelingModern ManMolecularMolecular InteractionMurineMusMutationOncogenesisOrganoidsPRO2286Pathway interactionsPatientsPharmaceutical PreparationsPhenotypePhosphorylationPlayPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProgrammed Cell DeathProliferatingProtein BindingProtein ModificationProtein PhosphorylationProteinsPublishingReceptor ProteinRecombinant DNA TechnologyRegulationRoleSignal TransductionSignal Transduction PathwaySignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinStrains Cell LinesTestingTissue GrowthTumor CellUbiquitilationUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3UbiquitinationUbiquitinoylationUnited StatesWNT Signaling PathwayWNT signalingWorkXenograftXenograft procedureXenotransplantationZebra DanioZebra FishZebrafishanti-cancerarmattenuateattenuatesbeta catbeta cateninbio-markersbiologic markerbiological signal transductionbiomarkerbound proteinbowelcancer cellcancer progressioncasein kinasecell behaviorcell growthcellular behaviorclinical relevanceclinically relevantcolorectal cancer progressioncultured cell linedevelopmentaldrug developmentdrug/agentdruggable targetfruit flygastrointestinal stem cellgenetically engineeredgenome mutationgut progenitorgut stem cellin vivoinhibitorinnovateinnovationinnovativeintestinal progenitorintestinal stem cellsloss of functionmalignancymembermultidisciplinaryneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenyoverexpressoverexpressionpathwayprogenitor cell maintenanceprogenitor maintenancereceptorreconstitutereconstitutionrecruitrepurposingsmall moleculesocial rolestem cell maintenancetranslational opportunitiestranslational potentialtreatment strategytumor growthtumor progressiontumorigenesisubiquinationubiquitin conjugationubiquitin-protein ligasexeno-transplantxeno-transplantationβ-catenin
Description preview
A Cereblon Signaling Network in Wnt-driven Cancers
Abstract
The long-term objective of this study is to investigate how Cereblon (CRBN) regulates the Wnt signal transduction
pathway and to demonstrate how this can be exploited to target Wnt-driven colorectal cancers (CRCs). Wnt
signaling is essential for intestinal stem cell maintenance and…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click