grant
A 4D-tunable hydrogel for the study of the impact of the tumor microenvironment on the development of colorectal cancer
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20253-D3-D modeling3-Dimensional3D3D modeling5-FU5-Fluracil5FUAnimal ModelAnimal Models and Related StudiesAnimalsApoptosisApoptosis PathwayArchitectureAutomobile DrivingBehaviorBiochemicalBiocompatible MaterialsBiologic ModelsBiological ModelsBiomaterialsBiomedical EngineeringBiophysicsBody TissuesCaCo2Caco-2 CellsCancer CauseCancer EtiologyCancersCell BodyCell FunctionCell PhysiologyCell ProcessCell RespirationCell-Extracellular MatrixCellsCellular FunctionCellular PhysiologyCellular ProcessCellular RespirationCessation of lifeCharacteristicsChemicalsColonColon CancerColon CarcinomaColon NeoplasmsColon TumorColonic MassColonic NeoplasmsColonic TumorColony-forming unitsColorectal CancerComplexCulture TechniquesCultured Neoplastic CellsCultured Tumor CellsDNA mutationData SetDeathDevelopmentDevicesDiseaseDisorderECMEngineering / ArchitectureEnvironmentEpithelial CellsEpitheliumEthicsEvolutionExtracellular MatrixFamily suidaeFibroblastsFluoro UracilFluorouracilFluoruracilFluouracilG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGC1GI Stem cellGPCRGW112GasesGeneticGenetic ChangeGenetic defectGenetic mutationGeographyGoalsGrowth AgentsGrowth FactorGrowth SubstancesHG38HealthHepaticHepatic CellsHepatic Neoplasm SecondaryHepatic Parenchymal CellHepatic metastasisHepatocyteHumanHydrogelsImageIn VitroIncidenceInternationalIntestinalIntestinesInvestigationInvestigatorsLGR5LGR5 geneLesion by StageLeucine-Rich RepeatLightLiver CellsLiver secondariesLiver secondary cancerMalignant NeoplasmsMalignant TumorMeasuresMetastatic Neoplasm to the LiverMetastatic Tumor to the LiverMetastatic breast cancerMetastatic malignant neoplasm to liverMiceMice MammalsMicrofluidic DeviceMicrofluidic Lab-On-A-ChipMicrofluidic MicrochipsModel SystemModelingModern ManMurineMusMutationNormal CellNuclear TranslocationO elementO2 elementOLFM4OLFM4 geneOlfactomedin 4OncogenesisOncogenicOncologyOncology CancerOpticsOrgan ModelOrganoidsOxidative PhosphorylationOxidative Phosphorylation PathwayOxygenPhotoradiationPhysiologicPhysiologicalPigsPlayPolypsPopulationPredispositionProcessProgenitor CellsProgrammed Cell DeathProliferatingPropertyProteins Growth FactorsProxyResearch PersonnelResearchersRight-Handed Beta-Alpha SuperhelixRoleScienceSmall IntestinesSubcellular ProcessSuidaeSusceptibilitySwineSystemTechnologyTestingTherapeuticTimeTissuesTumor CellWorkXenograft Modeladenomaaerobic metabolismaerobic respirationbio-engineeredbio-engineersbioengineeringbiological engineeringbiological materialbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencesbowelcancer in the coloncancer initiationcancer microenvironmentcancer progressioncancer typechemotherapychip modelchip systemcolon cancer tumorigenesiscolon neoplasiacolon tumorigenesiscolonic cryptcolorectal tumorigenesisdevelopmentaldrivingethicalexperimentexperimental researchexperimental studyexperimentsfabricationgastrointestinal stem cellgenome mutationgut progenitorgut stem cellhydrogel scaffoldimagingimprovedin vitro Modelin vivointestinal progenitorintestinal stem cellsliver metastasesmalignancymalignant liver neoplasm, specified as secondarymaterials sciencematrigelmetastasis in the livermetastasis to the livermetastasize to the livermetastatic breast tumormetastatic cancer to livermetastatic livermetastatic liver neoplasmmetastatic mammary cancermetastatic mammary tumormicrofluidic chipmicrophysiologic modelmicrophysiologic platformmicrophysiologic systemmicrophysiology modelmicrophysiology platformmicrophysiology systemmigrationmodel of animalmonolayermutantneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnovelon a chipon chipopticaloxidative metabolismpolyacrylamide hydrogelsporcinepreventpreventingprogenitor biologyprogenitor cell biologyprogenitor cell differentiationprogenitor cell markersprogenitor differentiationprogenitor markersprogenitor stem cell markersresponsescaffoldscaffoldingsecondary liver malignancysecondary malignant liver neoplasmsmall bowelsocial rolespheroidsstem and progenitor biologystem and progenitor differentiationstem cell biologystem cell biomarkersstem cell differentiationstem cell markersstem cellssubcutaneoussubdermalsuidthree dimensionalthree-dimensional modelingtissue culturetooltraittumortumor microenvironmenttumor progressiontumorigenesistumorigenicvirtualxenograft transplant modelxenotransplant model
Description preview
Project Summary/Abstract
The goal of this proposal is to develop a platform created from advanced biomaterials that enable novel
investigations into the physiochemical roles of the tumor microenvironment (TME) on the origins of
colorectal cancer. Colorectal cancer is a leading cause of cancer deaths in the U.S. and is increasing in
incidence.…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click