grant
A 3D zebrafish microanatomical and gene expression atlas for disease modeling
Organization PENNSYLVANIA STATE UNIV HERSHEY MED CTRLocation HERSHEY, UNITED STATESPosted 15 Aug 2025Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY202521+ years old3-D3-D Images3-D image3-D structure3-D visualization3-Dimensional3-dimensional structure3-dimensional visualization3D3D image3D images3D structure3D visualizationAccelerationAddressAdultAdult HumanAffectAnatomic ModelsAnatomic SitesAnatomic structuresAnatomical ModelsAnatomyAnimal ModelAnimal Models and Related StudiesAnimalsAtlasesAutomobile DrivingBiologic ModelsBiological MetamorphosisBiological ModelsBiologyBiomedical ResearchBody SystemBody TissuesBrachydanio rerioCell BodyCellsChemicalsChromosome MappingClinical InvestigatorCommunitiesConsultDNA mutationDanio rerioDataData SetDedicationsDevelopmentDevelopmental GeneDiseaseDisorderEducationEducational aspectsEducational workshopEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEnsureExpression SignatureFAIR dataFAIR guiding principlesFAIR principlesFeedbackFindable, Accessible, Interoperable and Re-usableFindable, Accessible, Interoperable, and ReusableFishesFoundationsFutureGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfileGene Expression ProfilingGene LocalizationGene MappingGene Mapping GeneticsGeneticGenetic ChangeGenetic defectGenetic mutationGenomicsGoalsHealthHistologicHistologicallyHistologyHistopathologyHumanHuman BiologyImageImaging DeviceImaging InstrumentImaging ToolIn Situ HybridizationInterdisciplinary ResearchInterdisciplinary StudyInvestigatorsKnowledgeLabelLifeLinkLinkage MappingMapsMicroanatomyMicroscopicMicroscopic AnatomyMicroscopyModel SystemModelingModern ManMolecularMultidisciplinary CollaborationMultidisciplinary ResearchMultiomic DataMutationNormal TissueNormal tissue morphologyOn-Line SystemsOnline SystemsOntologyOrganOrgan SystemOrganismPhenotypePhysiologicPhysiologicalPositionPositioning AttributePublic HealthReproducibilityResearchResearch PersonnelResearch ResourcesResearch SpecimenResearchersResolutionResourcesRoentgen RaysScanningScientistSliceSlideSpecimenSpottingsStructureTestingThickThicknessThree-Dimensional ImageTissuesTotal Human and Non-Human Gene MappingTranscript Expression AnalysesTranscript Expression AnalysisTranslationsValidationVisualizationWhole OrganismWorkWorkshopX-RadiationX-Ray RadiationX-rayX-ray microtomographyXrayXray microtomographyZebra DanioZebra FishZebrafishadulthoodanalyze gene expressionatlas resourcecell typeclinical phenotypeconsultsdevelopmentaldisease diagnosticdisease modeldisorder modeldrivingexperimentexperimental researchexperimental studyexperimentsgene expression analysisgene expression assaygene expression patterngene expression signaturegene functiongenetic mappinggenome editinggenome mutationgenome scalegenome-widegenomewidegenomic editinghealth literacyhigh resolution imaginghuman diseaseimagingimprovedin situ Hybridization Geneticsin situ Hybridization Staining Methodlife spanlifespanliving systemmetamorphosismicro CTmicro computed tomographymicroCTmicrotomographymodel of animalmodel organismmulti-modalitymultidisciplinarymultimodalitymultiple omic datamutantonline computeroutreachreconstructionresolutionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial relationshipspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssub micronsubmicronthree dimensionalthree dimensional structurethree-dimensional visualizationtooltranscriptional profiletranscriptional profilingtranscriptional signaturetranscriptomicstranslationusabilityuser-friendlyvalidationsvectorvirtualvirtual environmentweb based
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Project Summary
The zebrafish is a vertebrate model organism with significant genetic, cellular, and physiological similarities with
humans. Its powerful genetic and imaging tools have allowed us to decipher gene function, embryonic
development, and disease mechanisms. Its small size and recent advances in imaging allow the unbiased
visualization…
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