grant
3D micro-physiological systems for identification of therapeutic myokines
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAccountingAcuteAdult-Onset Diabetes MellitusAmentiaAnimal ModelAnimal Models and Related StudiesArteriesBindingBiochemicalBiologic ModelsBiological FunctionBiological MarkersBiological MimeticsBiological ModelsBiological ProcessBiologyBiomimeticsBiopsyBloodBlood Reticuloendothelial SystemBody TissuesCancersCardiacCardiovascular DiseasesCategoriesCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChemistryChronicCirculationClosure by LigationCommunicationCuesDementiaDetectionDiseaseDisorderDoseEndocrineEndocrine GlandsEndocrine OrgansEngineeringExerciseExercise TherapyExercise routineExtremitiesFactor AnalysesFactor AnalysisGeneticGoalsHindlimbHuman FigureHuman bodyHypoxiaHypoxicIn VitroIntracellular Second MessengerIschemiaIschemic HeartIschemic Heart DiseaseIschemic PreconditioningIschemic myocardiumKetosis-Resistant Diabetes MellitusLabelLeftLife StyleLifestyleLigationLimb structureLimbsMalignant NeoplasmsMalignant TumorMaturity-Onset Diabetes MellitusMechanicsMedicineMet-tRNA LigaseMethionine-tRNA LigaseMethionyl T RNA SynthetaseMethionyl-tRNA SynthetaseMicrofluidicsModel SystemMolecular InteractionMuscleMuscle Cell ContractionMuscle ContractionMuscle DiseaseMuscle DisordersMuscle ProteinsMuscle TissueMuscular ContractionMuscular DiseasesMyocardial IschemiaMyocardiumMyopathic ConditionsMyopathic Diseases and SyndromesMyopathic disease or syndromeMyopathyNIDDMNatureNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNon-TrunkNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityOperative ProceduresOperative Surgical ProceduresOpticsOrganOutcomeOxygen DeficiencyPatientsPhysical activityPhysiologicPhysiologicalPoint MutationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProtein BiosynthesisProtein ModificationProteinsProteomeProteomicsReceptor ProteinReporterReportingResearchRhodopsinRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSamplingSecond Messenger SystemsSecond MessengersSkeletal MuscleSlow-Onset Diabetes MellitusStable Diabetes MellitusSubcellular ProcessSurgicalSurgical InterventionsSurgical ProcedureSystemT2 DMT2DT2DMTestingTherapeuticTherapeutic exerciseTimeTissuesTourniquetsTransgenesTranslatingType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesValidationVascularizationVisual PurpleVoluntary MuscleWorkadiposityadult onset diabetesbio-markersbiologic markerbiomarkercardiac ischemiacardiac musclecardiovascular disordercell typechip modelchip systemcoronary ischemiacorpulencecost effectivecytokinedetection platformdetection systemendurance exerciseexercise regimenexercise trainingexercise treatmentheart ischemiaheart musclein vivoinnovateinnovationinnovativeketosis resistant diabetesmalignancymaturity onset diabetesmechanicmechanicalmicrophysiologic modelmicrophysiologic platformmicrophysiologic systemmicrophysiology modelmicrophysiology platformmicrophysiology systemminimally invasivemodel of animalmouse modelmurine modelmuscle regenerationmuscularmuscular disordermyocardial ischemia/hypoxiamyocardium ischemiamyogenesisneoplasm/cancernovelon a chipon chipopticaloptogeneticsprotective effectprotein synthesispublic health relevancereceptorsarcopeniasarcopenicsedentarysignal transduction second messengersskeletalsocial rolespatial and temporalspatial temporalspatiotemporalsurgerythree dimensionaltooltransgenetranslational opportunitiestranslational potentialtreadmilltreated with exercisetype 2 DMtype II DMtype two diabetesvalidationsµfluidic
Description preview
PROJECT SUMMARY
Skeletal muscle is a highly vascularized tissue that can secrete cytokines and proteins, collectively termed as
myokines. Despite the tremendous potential for translation, due to the dynamic nature of blood-borne factors,
reliable identification of these humoral factors remains a major hurdle. To overcome this challenge, Dr. Jang…
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