grant
2/2 PREEMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 30 Jul 2025Deadline 30 Jun 2032
NIHUS FederalResearch GrantFY202521+ years oldAIDS VirusASCVDAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAdultAdult HumanAgeAtherosclerosisAtherosclerotic Cardiovascular DiseaseBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBiometricsBiometryBiostatisticsBudgetsCalciumCardiac DiseasesCardiac DisordersCardiac arteryCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCholesterolClinicalClinical TrialsCoinColchicineCollaborationsCommunity OutreachConditioning TherapyConsentCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCoronary CT AngiographyCoronary arteryData AnalysesData AnalysisData CollectionData ReportingDeath RateDevelopmentDrugsEarly DiagnosisEarly treatmentElectronic Health RecordEligibilityEligibility DeterminationEnsureEvaluationFailureFamily memberGeneral HospitalsGeneral RadiologyGoalsGroups at riskGuidelinesHIVHeart DiseasesHeart VascularHeart arteryHospital DepartmentsHuman Immunodeficiency VirusesImageImage data archiveIndividualInflammationInformation TechnologyLAV-HTLV-IIILDLLDL LipoproteinsLaboratoriesLeadershipLife Style ModificationLipidsLow-Density LipoproteinsLymphadenopathy-Associated VirusMasksMeasurableMeasuresMedicationModelingMorbidityMorbidity - disease rateNHLBINational Heart, Lung, and Blood InstituteOutcomeParticipantPathogenesisPathway interactionsPeople at riskPersons at riskPharmaceutical PreparationsPlacebo ControlPlacebosPlayPopulationPopulations at RiskPreparationPreventative carePreventative strategyPreventative therapyPreventionPrevention strategyPrevention trialPreventive carePreventive strategyPreventive therapyPrimary PreventionProceduresProcessProtocol ScreeningPublic HealthQuality ControlRadiologyRadiology SpecialtyRandomization trialRandomizedRecommendationRiskRoleSafetySample SizeScanningSham TreatmentSpecific qualifier valueSpecifiedStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationTherapeuticUnited StatesVirus-HIVWeightWomanadjudicationadjudicative process and procedureadult youthadulthoodagedagesarmassess effectivenessassociate facultyassociate professoratheromatosisatherosclerosis riskatherosclerotic coronary diseaseatherosclerotic diseaseatherosclerotic riskatherosclerotic vascular diseasebehavior interventionbehavioral interventionbeta-Lipoproteinscardiac disease riskcardiac disorder riskcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcirculatory systemcompare effectivenesscomputed coronary angiography scanningcomputerized coronary tomography angiographycoronary CTAcoronary arterial diseasecoronary artery calcificationcoronary artery calciumcoronary artery calcium scoringcoronary calcificationcoronary calciumcoronary calcium scoringcoronary computed tomography angiographycoronary tomography angiographycostcurating datadata acquisitiondata acquisitionsdata curationdata interpretationdata managementdata representationdata representationsdata sharingdesigndesigningdetermine effectivenessdetermine efficacydevelopmentaldrug distributiondrug/agentearly detectionearly therapyeffectiveness assessmenteffectiveness evaluationefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordevaluate effectivenessevaluate efficacyexamine effectivenessexamine efficacyheart disease riskheart disorderheart disorder riskhigh riskimage archival systemimage archiveimage libraryimage repositoryimagingimaging repositoryimaging scienceimprovedintervention armlife-time risklifestyle modificationlifetime riskm-HealthmHealthmedical collegemedical schoolsmenmid lifemid-career facultymid-lifemidcareer facultymiddle agemiddle agedmidlifemobile healthmortalitymortality ratemortality ratioolder adultolder adulthoodoutreachpathwaypatient populationpharmacologicpicture archiveplacebo controlledpoint of careprematurepremature atherosclerosisprematuritypreparationspreventpreventingprimary end pointprimary endpointprofessorprognosticprospectiveprotocol developmentrandomisationrandomizationrandomized trialrandomly assignedresponserosuvastatinschool of medicinescreeningscreeningssham therapysocial mediasocial rolestatistical analysistooltreatment armtreatment effecttreatment strategytreatment trialweightsyoung adultyoung adult ageyoung adulthoodyounger age
Description preview
Abstract
Failure to detect and treat atherosclerosis in younger adults worsens cardiovascular morbidity and mortality.
Current strategies of assigning preventive therapies are not based on screening for atherosclerosis, but rather
on short-term risk scores that heavily weight age and leave most at-risk young and middle-aged adults
untreated. A new…
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