grant
2/2: PREcision VENTilation to attenuate Ventilation-Induced Lung Injury (PREVENT VILI)
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 1 Sept 2023Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY202521+ years oldARDSAcute Respiratory DistressAcute Respiratory Distress SyndromeAddressAdmissionAdmission activityAdultAdult ARDSAdult HumanAdult RDSAdult Respiratory Distress SyndromeAdverse ExperienceAdverse eventApplications GrantsAttenuatedAutomobile DrivingBiological MarkersBody WeightBreathingBreathing MechanicsCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 associated deathCOVID-19 associated fatalityCOVID-19 associated mortalityCOVID-19 crisisCOVID-19 deathCOVID-19 epidemicCOVID-19 eraCOVID-19 fatalityCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 induced deathCOVID-19 induced fatalityCOVID-19 induced mortalityCOVID-19 mortalityCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 related deathCOVID-19 related fatalityCOVID-19 related mortalityCOVID-19 yearsCOVID19 associated deathCOVID19 associated fatalityCOVID19 associated mortalityCOVID19 deathCOVID19 fatalityCOVID19 induced deathCOVID19 induced fatalityCOVID19 induced mortalityCOVID19 mortalityCOVID19 related deathCOVID19 related fatalityCOVID19 related mortalityCase Report FormCause of DeathCirculatory CollapseClinicalClinical Trials Data Monitoring CommitteesCollaborationsCommunicationConsentCritical IllnessCritically IllDa Nang LungDataData CollectionData Coordinating CenterData Coordination CenterData Monitoring CommitteesData SetData and Safety Monitoring BoardsElectronicsEnrollmentEnsureFeedbackFosteringFunding AgencyFunding SourceGoalsGrantGrant ProposalsHealth Care SystemsHistoryInfrastructureInjuryInstructionInterventionInvestigationInvestigatorsLaboratoriesLungLung Respiratory SystemLung damageMaintenanceManuscriptsMeasurementMeasuresMechanical ventilationMethodologyMonitorMorbidityMorbidity - disease rateNewsletterOutcomeParticipantPatientsPersonalized medical approachPhasePhysiologicPhysiologicalPopulationPositive End-Expiratory PressurePositive-Pressure RespirationPreparationPreventative strategyPrevention strategyPreventive strategyProtocolProtocol ComplianceProtocols documentationQuality ControlRandomization trialRandomized, Controlled TrialsRecording of previous eventsRecoveryReportingReproducibilityResearchResearch PersonnelResearchersRespiratory AspirationRespiratory InspirationRespiratory MechanicsRiskSARS-CoV-2 associated deathSARS-CoV-2 associated fatalitySARS-CoV-2 associated mortalitySARS-CoV-2 deathSARS-CoV-2 epidemicSARS-CoV-2 fatalitySARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 induced deathSARS-CoV-2 induced fatalitySARS-CoV-2 induced mortalitySARS-CoV-2 mortalitySARS-CoV-2 pandemicSARS-CoV-2 related deathSARS-CoV-2 related fatalitySARS-CoV-2 related mortalitySARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSafety Monitoring BoardsSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicShockShock LungSiteStiff lungStressTechniquesTeleconferencesTestingTidal VolumeTimeTitrationsVentilatorVentilator-induced lung injuryadulthoodarmatelectraumaattenuateattenuatesbio-markersbiologic markerbiomarkercare as usualcirculatory shockcommunity engagementconferenceconventioncoronavirus disease 2019 associated deathcoronavirus disease 2019 associated fatalitycoronavirus disease 2019 associated mortalitycoronavirus disease 2019 crisiscoronavirus disease 2019 deathcoronavirus disease 2019 epidemiccoronavirus disease 2019 fatalitycoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 induced deathcoronavirus disease 2019 induced fatalitycoronavirus disease 2019 induced mortalitycoronavirus disease 2019 mortalitycoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease 2019 related deathcoronavirus disease 2019 related fatalitycoronavirus disease 2019 related mortalitycoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 mortalitycoronavirus disease-19 pandemiccostdata managementdeath due to COVID-19death due to COVID19death due to SARS-CoV-2death due to coronavirus disease 2019death due to severe acute respiratory syndrome coronavirus 2death in COVIDdeath in COVID-19death in SARS-CoV-2death in coronavirus diseasedeath in coronavirus disease 2019death in severe acute respiratory syndrome coronavirus 2designdesigningdrivingefficacy testingelectronicelectronic data capture systemelectronic deviceengagement with communitiesenrollevidence baseexpirationfatality due to COVID-19fatality due to COVID19fatality due to SARS-CoV-2fatality due to coronavirus disease 2019fatality due to severe acute respiratory syndrome coronavirus 2hemodynamicshigh riskhigh standardhistoriesimprovedindividualized approachindividualized strategiesinjuriesinnovateinnovationinnovativeinspirationintervention armlung injurylung pressuremechanical respiratory assistmechanically ventilatedmeetingmeetingsmortalitymortality due to COVID-19mortality due to COVID19mortality due to SARS-CoV-2mortality due to coronavirus disease 2019mortality due to severe acute respiratory syndrome coronavirus 2novelpatient centeredpatient orientedpatient safetypersonalized approachpersonalized strategiespositive pressure breathingpre-pandemicprecision approachpreparationspressurepreventpreventingprimary outcomeprospectiveprotocol developmentpulmonarypulmonary damagepulmonary injurypulmonary pressurepulmonary tissue damagepulmonary tissue injuryrandomized control trialrandomized trialrespiratoryrespiratory airway volumesafety assessmentsevere acute respiratory syndrome coronavirus 2 associated deathsevere acute respiratory syndrome coronavirus 2 associated fatalitysevere acute respiratory syndrome coronavirus 2 associated mortalitysevere acute respiratory syndrome coronavirus 2 deathsevere acute respiratory syndrome coronavirus 2 fatalitysevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsevere acute respiratory syndrome coronavirus 2 induced deathsevere acute respiratory syndrome coronavirus 2 induced fatalitysevere acute respiratory syndrome coronavirus 2 induced mortalitysevere acute respiratory syndrome coronavirus 2 mortalitysevere acute respiratory syndrome coronavirus 2 related deathsevere acute respiratory syndrome coronavirus 2 related fatalitysevere acute respiratory syndrome coronavirus 2 related mortalityshocksstandard carestandard of carestandard treatmentstatistical centersummitsupport toolssymposiasymposiumtailored approachtreatment armtreatment as usualtrial planningusual careusual care armusual care control groupventilationventilation induced lung injuryventilator associated lung injuryweb sitewebsitewet lung
Description preview
PROJECT SUMMARY / ABSTRACT
Acute respiratory distress syndrome (ARDS) occurs in up to one-quarter of all critically ill adults receiving
mechanical ventilation and is associated with high risk of morbidity and mortality, which is compounded by
ventilation-induced lung injury (VILI). Current ventilation strategies and standard care attempt to…
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