grant
17α-estradiol and sex-differences in HAND with methamphetamine
Organization UNIVERSITY OF NORTH DAKOTALocation GRAND FORKS, UNITED STATESPosted 1 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcquired brain injuryAffectAmmon HornAnti-Retroviral AgentsAquadiolAxonBrainBrain InjuriesBrain Nervous SystemCNS plasticityCognitionCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCommon Rat StrainsComplexCornu AmmonisCrystal MethCrystal methamphetamineDendritic SpinesDeoxyephedrineDesoxyephedrineDevelopmentDifferences between sexesDiffers between sexesDimenformonDiogynDiogynetsDisturbance in cognitionDrugsDysfunctionERalphaERαESR1ESR1 geneEncephalonEstraceEstradiolEstradiol Receptor alphaEstradiol Receptor αEstradiol-17 betaEstradiol-17betaEstraldineEstrogen Receptor 1Estrogen Receptor alphaEstrogen Receptor αEstrogensEvaluationFemaleFunctional disorderHIVHIV 1 associated neurocognitive disorderHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV env Protein gp120HIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV neurocognitive impairmentHIV-1HIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-IHIV-associated neurocognitive disorderHIV1HTLV-III gp120HippocampusHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1IQ DeficitImpaired cognitionImpairmentIn VitroIsoformsLAV-HTLV-IIILearningLymphadenopathy-Associated VirusMedicationMembraneMethamphetamineMethamphetamine misuseMethylamphetamineN-MethylamphetamineNR3A1Nerve CellsNerve UnitNeural CellNeurocognitive DeficitNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1NeurocyteNeuronal PlasticityNeuronsOvocyclinOvocylinPathogenesisPharmaceutical PreparationsPhysiopathologyPlayPrevalencePreventative interventionProcessProductionProgynonProtein IsoformsProteinsRatRats MammalsRattusRoleSex DifferencesSexual differencesSiteSolidTestingTherapeuticTherapeutic EstradiolTherapeutic EstrogenTherapeutic InterventionViral Gene ProductsViral Gene ProteinsViral ProteinsVirus-HIVWomanWorkabused drugabused drugsanti-retroviralantiretroviral therapyantiretroviral treatmentbrain damagebrain-injuredcentral nervous system plasticityco-morbidco-morbiditycognitive defectscognitive dysfunctioncognitive losscomorbiditydendrite spinedensitydevelopmentaldrug abuseddrug of abusedrug/agentdrugs abuseddrugs of abusegp120gp120 ENV Glycoproteingp120(HIV)gray matterhippocampalin vivo Modelinsightintelligence quotient deficitintervention for preventionintervention therapyknock-downknockdownmalemembrane structuremethmeth misusemutantneural plasticityneurocognitive declineneurocognitive impairmentneuronalneuroplasticneuroplasticityneuroprotectionneuroprotectivenoveloverexpressoverexpressionpathophysiologypreventpreventingprevention interventionpreventional intervention strategypreventive interventionprotective effectpsychostimulant misusepsychostimulant usesex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolestimulant misusestimulant usesubstantia griseatraffickinguse of stimulantsvirus protein♀♂
Description preview
Project Abstract
The pathogenesis of HIV-associated neurocognitive disorders (HAND) in ART era is complex and may result
from low levels of HIV-1 replication/HIV-1 proteins, ART drugs, drug of abuse, and the misuse of stimulants
such as methamphetamine. It is envisioned that combined exposure of these HIV-related factors leads to
reversible…
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