grant
1/3 Eating Disorders Genetics Initiative 2 (EDGI2)
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 13 May 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2025Adipose tissueAllelesAllelomorphsAnorexia NervosaAtlasesAustraliaBMIBMI percentileBMI z-scoreBehaviorBinge eating disorderBioinformaticsBiologyBody TissuesBody mass indexBrainBrain Nervous SystemBulimiaBulimia NervosaBusinessesCausalityCell AnatomyCellular AnatomyClinicalClinical ResearchClinical StudyCollectionCommunitiesDNADataDenmarkDeoxyribonucleic AcidDiagnosisDiagnosticDimensionsDiseaseDisorderEating DisordersEncephalonEnrollmentEnvironmental ExposureEnvironmental FactorEnvironmental Risk FactorEtiologyFatty TissueGTExGWA studyGWASGene ExpressionGeneral TaxonomyGenesGeneticGenetic DiseasesGenetic RiskGenomicsGenotypeGenotype-Tissue Expression ProjectGoalsGroupingHeritabilityHeterogeneityHuman ResourcesIndividualInterventionKnowledgeLiverManpowerMendelian randomizationMental DepressionMental disordersMental health disordersMeta-AnalysisMetabolicMetabolic DiseasesMetabolic DisorderMethodsMexicoMinorityMinority EnrollmentModelingMolecularMuscleMuscle TissueNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNeurosciencesNew ZealandParticipantPathway interactionsPatternPhasePhenotypePredicting RiskProductionProductivityPsychiatric DiseasePsychiatric DisorderPsychiatryQuetelet indexRegional AnatomyResearch ResourcesResourcesRoleSalivarySample SizeSamplingScienceSeveritiesSingle-Nucleus SequencingSiteStressStressful EventSubcellular AnatomySwedenSymptomsTaxonomyTherapeuticThesaurismosisThinkingTissuesUnderrepresented GroupsUnderrepresented PopulationsVariantVariationWeight GainWeight Increaseadiposeavoidant restrictive food intake disorderbody weight gainbody weight increasebrain cellbulimiccausationcell typeclinical translationclinically translatableco-morbidco-morbiditycohortcommunity marginalizationcommunity partnerscommunity-based partnerscomorbidityconferenceconventiondepressiondevelop therapydisease causationdisease preventiondisorder preventionenrollenvironmental riskevidence baseexpression subtypesforecasting riskgenetic analysisgenetic conditiongenetic disordergenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygroupingshepatic body systemhepatic organ systeminnovateinnovationinnovativeinsightintervention developmentlow-frequency mutationmarginalizationmarginalized communitymental illnessmetabolism disorderminority communitiesmolecular sub-typesmolecular subsetsmolecular subtypesmuscularneurological diseasenovelpathwaypatient stratificationpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespersonnelpolygenetic risk scorespolygenic risk scorepredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskpsychiatric genomicspsychiatric illnesspsychological disorderrare allelerare mutationrare variantrecruitresilience factorresiliency factorresponserisk predictionrisk predictionssNuc-Seqsexsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial mediasocial rolestratified patientstressful experiencestressful life eventstressful life experiencesummitsymposiasymposiumtherapy developmentthoughtstraittreatment developmentunder representation of groupsunder represented groupsunder represented peopleunder represented populationsunderrepresentation of groupsunderrepresented peoplewhite adipose tissuewhole genome association analysiswhole genome association studywork groupworking groupwt gainyellow adipose tissue
Description preview
PROJECT SUMMARY
We propose the Eating Disorders Genetics Initiative 2 (EDGI2), a new collaborative R01 in response to PAR-
23-050 Clinical Studies of Mental Illness. Its single-site predecessors, EDGI1 (R01 MH120170) and ARFID-GEN
(R56 MH129437) have been resoundingly successful. We now unite the four original EDGI1 sites with
exceptionally…
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