grant
1/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 25 Sept 2017Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025Academic Medical CentersAccelerationActive Follow-upAcuteAddressAfrican AmericanAfrican ancestryAfrican descentAfro AmericanAfroamericanAlbuminsAllograftingAmericanAntibodiesApolipoproteinsBacterial InfectionsBloodBlood Reticuloendothelial SystemBlood SerumCaringClinicClinical DataConsentCost SavingsCounselingCreatinineDNADataDeoxyribonucleic AcidDisparitiesDisparityDonor personEducationEducational aspectsEnrollmentEnsureEnvironmental FactorEnvironmental Risk FactorEuropeanEvaluationFaceFailureGene variantGenesGeneticGenetic predisposing factorGenotypeGeographyGraft SurvivalHL-A AntigensHLA AntigensHuman Leukocyte AntigensImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInjuryInterventionIowaKidneyKidney FailureKidney GraftingKidney InsufficiencyKidney TransplantationKidney TransplantsKidney Urinary SystemLesionLeukocyte AntigensLiving DonorsLong-term Follow-upMeasuresMedicalMinnesotaMonitorNational Institutes of HealthNebraskaOrganOutcomeOutcome StudyParticipantPatternPhasePhenotypePoliciesPrevalenceProteinuriaPublic HealthQOLQuality of lifeRecurrent diseaseRegistriesRelapsed DiseaseRelative RisksRenal FailureRenal GraftingRenal InsufficiencyRenal TransplantationRenal TransplantsRenal functionReportingResearchRiskRisk-associated variantRoleSafetySerumTimeTransplant RecipientsTransplantationUNOSUnited Network for Organ SharingUnited States National Institutes of HealthUniversitiesUniversity Medical CentersUrineVariantVariationViral DiseasesVirus DiseasesWisconsinactive followupallelic variantbacteria infectionbacterial diseasebasebasesclinical centercohortdeceased donordeceased organ donorsdifferences due to racedifferences in racediffers by racediffers in raceenrollenvironmental riskethnic differenceethnicity differencefacesfacialfollow upfollow-upfollowed upfollowupgene interactiongenetic risk factorgenetic variantgenomic variantgraft failuregraft functionhigh riskimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedinherited factorinjurieskidney biopsykidney functionkidney txlive kidney donorliving kidney donorlong-term followupnovelpost-transplantpost-transplantationposthumous donorsposthumous organ donorposttransplantposttransplantationprimary outcomeprogramsprospectiverace based differencesrace differencesrace related differencesracial differenceracially differentrecruitrenalrenal biopsyrisk allelerisk generisk genotyperisk locirisk locusrisk variantsecondary outcomesocial roletransplanttransplant donortransplant patientviral infectionvirus infectionvirus-induced disease
Description preview
PROJECT SUMMARY/ABSTRACT
Recipients of a kidney transplant from an African-American deceased donor have worse outcomes than
their counterparts receiving an organ from a European-American deceased donor. In addition, kidney
transplants from deceased donors with two apolipoprotein L1 gene (APOL1) high-risk genotypes, which is
almost exclusively…
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